Medical bleeding denotes hemorrhage as a result of an underlying medical condition

Image Intravascular changes - changes of the blood within vessels (e.g. ↑ blood pressure, ↓ clotting factors) Intramural changes - changes arising within the walls of blood vessels (e.g. aneurysms, dissections, AVMs, vasculitides) Extravascular changes - changes arising outside blood vessels (e.g. H pylori infection, brain abscess, brain tumor) The underlying scientific basis for blood clotting and hemostasis is discussed inH detail in the articles, coagulation, hemostasis and related articles. The discussion here is limited to the common practical aspects of blood clot formation which manifest as bleeding. Some medical conditions can also make patients susceptible to bleeding. These are conditions that affect the normal hemostatic (bleeding-control) functions of the body. Such conditions either... Read More

Hemorrhaging is broken down into four classes by the American College of Surgeons' advanced trauma life support (ATLS).

Image Class I Hemorrhage involves up to 15% of blood volume. There is typically no change in vital signs and fluid resuscitation is not usually necessary. Class II Hemorrhage involves 15-30% of total blood volume. A patient is often tachycardic (rapid heart beat) with a reduction in the difference between the systolic and diastolic blood pressures. The body attempts to compensate with peripheral vasoconstriction. Skin may start to look pale and be cool to the touch. The patient may exhibit slight changes in behavior. Volume resuscitation with crystalloids (Saline solution or Lactated Ringer's solution) is all that is typically required. Blood transfusion is not usually required. Class III Hemorrhage involves loss of 30-40%... Read More

Placing the practice of medicine in perspective while that mistakes are not isolated During the process

Image Journal of Kidney Treatment and Diagnosis is a peer-reviewed Journal, encourages on-going international research and information exchange through publication of latest advances on all aspects of Kidney Treatment and Diagnosis. Some physicians recognize that adverse outcomes from errors usually do not happen because of an isolated error and actually reflect system problems. This concept is often referred to as the Swiss Cheese Model. This is the concept that there are layers of protection for clinicians and patients to prevent mistakes from occurring. Therefore, even if a doctor or nurse makes a small error (e.g. incorrect dose... Read More

Psychological disorders that causes during Misdiagnosis

Image Journal of Kidney Treatment and Diagnosis is a peer-reviewed Journal, encourages on-going international research and information exchange through publication of latest advances on all aspects of Kidney Treatment and Diagnosis. Female sexual desire sometimes used to be diagnosed as female hysteria. Sensitivities to foods and food allergies risk being misdiagnosed as the anxiety disorder Orthorexia. Studies have found that bipolar disorder has often been misdiagnosed as major depression. Its early diagnosis necessitates that clinicians pay attention to the features of the patient's depression and also look for present or prior hypomanic or manic symptomatology. The misdiagnosis of schizophrenia is also a common problem. There may be long delays of patients getting... Read More

Interviews with patients and families reported

Image Journal of Kidney Treatment and Diagnosis is a peer-reviewed Journal, encourages on-going international research and information exchange through publication of latest advances on all aspects of Kidney Treatment and Diagnosis. Gallagher et al. state that patients want "information about what happened, why the error happened, how the error's consequences will be mitigated, and how recurrences will be prevented." Interviews with patients and families reported in a 2003 book by Rosemary Gibson and Janardan Prasad Singh, put forward that those who have been harmed by medical errors face a "wall of silence" and "want an acknowledgement" of... Read More

Errors include in diagnosis

Image Journal of Kidney Treatment and Diagnosis is a peer-reviewed Journal, encourages on-going international research and information exchange through publication of latest advances on all aspects of Kidney Treatment and Diagnosis. Errors can include misdiagnosis or delayed diagnosis, administration of the wrong drug to the wrong patient or in the wrong way, giving multiple drugs that interact negatively, surgery on an incorrect site, failure to remove all surgical instruments, failure to take the correct blood type into account, or incorrect record-keeping. A 10th type of error is ones which are not watched for by researchers, such as RNs failing to program an IV... Read More

Inflammatory bowel disease – Symptoms, Causes, Risk Factors and Complications

Image Inflammatory bowel disease – Symptoms, Causes, Risk Factors and Complications Journal of Food and Clinical Nutrition is a peer reviewed open access journal. Inflammatory bowel disease – Symptoms, Causes, Risk Factors and Complications are described below. Inflammatory bowel disease (IBD) is an umbrella term used to describe disorders that involve chronic inflammation of your digestive tract. Types of IBD include: Ulcerative colitis. This condition causes long-lasting inflammation and sores (ulcers) in the innermost lining of your large intestine (colon) and rectum. Crohn's disease. This type of IBD is characterized by inflammation of the lining of your digestive tract, which often spreads deep... Read More

Food additives and its Categories

Image Food additives and its Categories Journal of Food and Clinical Nutrition is a peer reviewed open access journal. Food additives and its Categories are described below. Food additives are substances added to food to preserve flavor or enhance its taste, appearance, or other qualities. Some additives have been used for centuries; for example, preserving food by pickling (with vinegar), salting, as with bacon, preserving sweets or using sulfur dioxide as with wines. With the advent of processed foods in the second half of the twentieth century, many more additives have been introduced, of both natural and artificial origin. Food additives also include substances that may be introduced to food indirectly (called "indirect additives") in the... Read More

Back in Circulation from Lymphedema

Image An Abnormal Buildup of Fluid Over 250 million people worldwide have lymphedema, mostly as a result of parasitic infection from roundworm. However, in developed countries, the leading cause is damage to the lymphatic system because of cancer treatment. The condition can arise after surgery or radiation treatment for nearly any type of cancer but is most commonly linked to breast, prostate and pelvic area cancers (such as bladder, penile, testicular, endometrial, vulvar and cervical cancers), lymphoma, melanoma, and head and neck cancers. The lymphatic system consists of a complex network of... Read More

Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria

Image The liver is an important site of replication for Plasmodium parasites, and therefore a key goal in vaccination against malaria is to induce robust antiparasitic immunity in the liver. Using Plasmodium berghei as a model to study malaria in mice, Holz et al. have developed a glycolipid-peptide conjugate vaccine that induced robust T cell responses in the liver and was able to protect mice when challenged with P. berghei. Inclusion of the glycolipid adjuvant, α-galactosylceramide (α-GalCer) that activates natural killer T (NKT) cells was vital to promoting antiparasitic immunity in the liver. The authors propose that agonists that activate NKT... Read More

Researcher's destroy cancer cells with ultrasound treatment.

Image An international research team led by Dr. Tali Ilovitsh of the Biomedical Engineering Department at Tel Aviv University developed a noninvasive technology platform for gene delivery into breast cancer cells. The technique combines ultrasound with tumor-targeted microbubbles. Once the ultrasound is activated, the microbubbles explode like smart and targeted warheads, creating holes in cancer cells' membranes, enabling gene delivery. Conducted over two years, the research was published on June 9 in the journal Proceedings of the National Academy of Sciences (PNAS). Dr. Ilovitsh developed this breakthrough technology during her post-doctorate research at the lab of Prof. Katherine Ferrara at Stanford... Read More

Helminthiasis

Image On behalf of the Journal of Immune Disorder and Therapy : Open Access, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we are privileged to welcome clinical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of immune disorder and therapy: Open Access. The Journal of Immune Disorder and Therapy : Open Access aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Cancer. The open access journal... Read More

Immune deficiency in new-borns

Image On behalf of the Journal of Immune Disorder and Therapy : Open Access, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we are privileged to welcome clinical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of immune disorder and therapy: Open Access. The Journal of Immune Disorder and Therapy : Open Access aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Cancer. The open access journal... Read More

Clinical Association of Antinuclear Antibodies (ANA) Anti-NuMA1 and Anti-NuMA2

Image The prevalence of anti-NuMA1 and anti-NuMA2 antibodies in autoimmune, hepatic, infectious and renal inflammatory diseases is well known; however, its presence and possible relevance in cardiovascular diseases still needs to be elucidated. Aim: To evaluate the prevalence of positive anti-NuMA1 and anti-NuMA2 antibody patterns in subjects with autoimmune, non-autoimmune and/or cardiac diseases. Material and methods: This was an observational study run from January 2010 to January 2018. Individuals whose treating physician requested an antibody study and we detected anti NuMA1 and anti NuMA2 pattern in any patients. The files from these patients were reviewed to obtain general data, signs, symptoms,... Read More

Oral Manifestations of Menopause

Image Basic and Clinical Reproductive Sciences is an elite, highly cited, scientific open access journal that publishes peer reviewed, original research and review articles in the field of Reproductive science and medicine. The Journal aims to render a global platform for scientists and academicians to discuss and share numerous developments and issues related to Reproductive science. The journal provides multi-disciplinary interpretation of the latest research advances in different aspects of basic and clinical reproductive science and medicine, including basic reproductive biology, maternal-foetal medicine, obstetrics, gynaecology, gestation, reproductive endocrinology, uro-gynaecology, and embryology as research articles, review articles, short communications,... Read More

Causes and symptoms of male infertility

Image The Journal of Basic and Clinical Reproductive Sciences (JBCRS) is devoted to convey and spread to its researchers around the world, the latest knowledge in relation to the recent advances in the field of Reproductive Sciences. The journal includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises a peer review process for the submitted manuscripts for the quality of publishing. Aim is to catalogue the current scholarly information sourced from across the world and broadcast to maximize in reliable... Read More

First spherical artificial eye has 3D retina

Image First spherical artificial eye has 3D retina Scientists have developed the world's first 3D artificial eye with capabilities better than existing bionic eyes and in some cases, even exceed those of the human eyes, bringing vision to humanoid robots and new hope to patients with visual impairment. The working principle of the artificial eye involves an electrochemical process which is adopted from a type of solar cell. In principle, each photo sensor on the artificial retina can serve as a nanoscale solar cell. With further modification, the EC-Eye can be a self-powered image sensor, so there is no need... Read More

Early Childhood

Image Journal of Child Psychology is an excellent source of information concerning all aspects of the development of children. It includes empirical psychological research on cognitive, social/emotional, and physical development. In addition, the journal periodically publishes Special Topic issues. Contributors are welcome to publish high quality clinical, and laboratory research papers, case series, reviews, guidelines, techniques, and practice manuscripts related to all aspects of emotional and intellectual well  being of children and adolescents. Author (s) may submit their manuscripts through online link https://www.pulsus.com/submissions/child-psychology.html or as an e-mail attachment childpsychol@scholarlypub.com... Read More

Children's Emotional Development

Image The Journal of Child Psychology brings together the latest innovative research that advances knowledge of psychopathology from infancy through adolescence. The journal publishes studies that have a strong theoretical framework and use a diversity of methods, with an emphasis on empirical studies of the major forms of psychopathology found in childhood disorders (e.g., disruptive behavior disorders, depression, anxiety, and autism spectrum disorder). Studies focus on the epidemiology, etiology, assessment, treatment, prognosis, and developmental course of these forms of psychopathology. Studies highlighting risk and protective factors; the ecology and correlates of children's emotional, social, and behavior problems; and advances in prevention... Read More

Nonalcoholic fatty liver disease and its prevention

Image Nonalcoholic fatty liver disease and its prevention Journal of Food and Clinical Nutrition is a peer reviewed open access journal. Nonalcoholic fatty liver disease and its prevention is described below. Nonalcoholic fatty liver disease (NAFLD) is an umbrella term for a range of liver conditions affecting people who drink little to no alcohol. Some individuals with NAFLD can develop nonalcoholic steatohepatitis (NASH), an aggressive form of fatty liver disease, which is marked by liver inflammation and may progress to advanced scarring (cirrhosis) and liver failure. This damage is similar to the damage caused by heavy alcohol use. Causes Overweight or obesity Insulin... Read More

Lymph sacs

Image Lymph sacs are a part of the development of the lymphatic system, known as lymphangiogenesis.The lymph sacs are precursors of the lymph vessels.These sacs develop through the processes of vasculogenesis and angiogenesis. However, there is evidence of both of these processes in different organisms. In mice, it is thought that the lymphatic components form through an angiogenic process. But, there is evidence from bird embryos that gives rise to the idea that lymphatic vessels arise in the embryos through a vasculogenesis-like process from the lymphangioblastic endothelial precursor cells. The development of the lymphatic system has been a highly debated topic... Read More

Persistent generalized lymphadenopathy

Image Persistent generalized lymphadenopathy (PGL) is enlarged, painless, non-tender lymph nodes occurring in a couple of different areas for more than three to six months for which no other reason can be found. This condition occurs frequently in people in the latency period of HIV/AIDS. The lymphatic system is part of the immune surveillance system. Blood contains fluid and blood cells. The fluid, which may contain suspended foreign material such as bacteria and viruses, seeps through blood vessel walls into the tissues, where it bathes the body cells and exchanges substances with them. Some of this lymph fluid is then taken... Read More

High cholesterol- Risk factors, Complications and Prevention

Image High cholesterol- Risk factors, Complications and Prevention Journal of Food and Clinical Nutrition is a peer reviewed open access journal. High cholesterol-Risk factors, Complications and Prevention is given below which is related to food and clinical nutrition. Cholesterol is a waxy substance found in your blood. Your body needs cholesterol to build healthy cells, but high levels of cholesterol can increase your risk of heart disease. With high cholesterol, you can develop fatty deposits in your blood vessels. Eventually, these deposits grow, making it difficult for enough blood to flow through your arteries. Sometimes, those deposits can break suddenly and form... Read More

Intravenous versus Subcutaneous Immunoglobulin in Primary Immunodeficiency: Real-World Evaluation of Safety, Efficacy, and Patient Perceptions

Image Background: Patients with primary immunodeficiency disorders (PIDD) typically require life-long immunoglobulin (IG) replacement therapy. There are two routes of IG administration: intravenous (IVIG) and subcutaneous (SCIG). To better understand routes of IG administration in the real-world, use in a home infusion setting was evaluated. Objective: To evaluate the safety, efficacy, and perceived responses in PIDD patients on IVIG versus SCIG in a realworld, home infusion setting. Methods: Retrospective data were collected from 2010 to 2018 from a national home infusion pharmacy of PIDD patients receiving IVIG or SCIG therapy for at least 6 months with evaluations for safety, efficacy, and... Read More

Ethical, Legal n Social Issues in Non-Medical Use of Drugs

Image Journal of Clinical Pharmacology and Toxicology is using Editorial Tracking System to maintain quality and transparency to the author in the peer-review process. Review processing will be performed by the editorial board members of the Journal of Clinical Pharmacology and Toxicology or by Reviewers (outside experts in the field). Two independent reviewer’s approval (Minimum reviewer’s approval) followed by editor approval is obligatory for acceptance of any manuscript excluding an editorial. Various academic disciplines are increasingly concerned with uses of pharmaceuticals (e.g., opioids, stimulants) and other substances (e.g., cannabis) for uses that fall outside the... Read More

Nanotechnology Solutions Mitigate COVID-19 : Detection, Protection, Medication

Image Journal of Clinical Pharmacology and Toxicology is using Editorial Tracking System to maintain quality and transparency to the author in the peer-review process. Review processing will be performed by the editorial board members of the Journal of Clinical Pharmacology and Toxicology or by Reviewers (outside experts in the field). Two independent reviewer’s approval (Minimum reviewer’s approval) followed by editor approval is obligatory for acceptance of any manuscript excluding an editorial. Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At the time of writing on 7th... Read More

This vaccine may protects against worst symptoms of COVID-19

Image The MMR (measles, mumps, rubella) vaccine could serve as a preventive measure to dampen septic inflammation associated with COVID-19 infection, say researchers. According to the study, published in the journal mBio, vaccination with MMR in immunocompetent individuals has no contraindications and may be especially effective for health care workers who can easily be exposed to COVID-19. "Live attenuated vaccines seemingly have some nonspecific benefits as well as immunity to the target pathogen. A clinical trial with MMR in high-risk populations may provide a low-risk-high-reward preventive measure in saving lives during the COVID-19 pandemic," said study researcher Paul Fidel from the... Read More

Male infertility

Image The Journal of Basic and Clinical Reproductive Sciences (JBCRS) is devoted to convey and spread to its researchers around the world, the latest knowledge in relation to the recent advances in the field of Reproductive Sciences. The journal includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises a peer review process for the submitted manuscripts for the quality of publishing. Many infertile couples have more than one cause of infertility, so it's likely you will both need to see... Read More

Journal of Basic and Clinical Reproductive Sciences Invites Manuscripts for Volume 9, Issue 2

Image Journal of Basic and Clinical Reproductive Sciences is an academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide. The journal selects the articles to be published with a single bind, peer review system, following the practices of good scholarly journals. It supports the open access policy of making scientific research accessible to one... Read More

Ophthalmic manifestations of sickle cell disease: update of the latest findings

Image Ophthalmic manifestations of sickle cell disease: update of the latest findings Recent developments in the diagnosis and management of sickle cell ocular manifestations are reviewed to enable the clinician to better manage the ophthalmic care of these patients. Research over the past year has focused upon systemic and ocular clues to the presence of sickle cell retinopathy. In addition, newer imaging modalities, such as spectral domain optical coherence tomography and wide-field imaging, have resulted in the detection of subclinical retinopathy related to sickle cell disease. Decreased retinal function (via microperimetry testing) has also been detected in association with areas... Read More

ANAPHYLAXIS

Image On behalf of the Journal of Immune Disorder and Therapy : Open Access, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we are privileged to welcome clinical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of immune disorder and therapy: Open Access. The Journal of Immune Disorder and Therapy : Open Access aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Cancer. The open access journal... Read More

Arteriosclerotic Aortic Disease

Image On behalf of the Journal of Immune Disorder and Therapy : Open Access, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we are privileged to welcome clinical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of immune disorder and therapy: Open Access. The Journal of Immune Disorder and Therapy : Open Access aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Cancer. The open access journal... Read More

Systems Biology for Understanding Cancer Biology

Image During last decades the theoretical framework in carcinogenesis studies has been provided by the Somatic Mutation Theory (SMT). SMT envisions understanding cancer at the cellular level of organization, by claiming that cancer is a problem of regulatory control of cell proliferation and invasiveness, mainly due to mutations and/or deregulation of a specific class of genes Even though SMT has fostered a meaningful development of molecular-based technologies, on the other hand that approach has encompassed an increasing number of experimental results that contradict its premises . Additionally, current therapeutic approaches based on SMT have been proven to be ineffective in clinical... Read More

Synthetic cell biology

Image The Current Synthetic and Systems Biology aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to like molecular biology, theoretical biology, structural biology, marine biology etc.. Synthesis of data into formal models of cellular function is rapidly becoming a necessary industry. The complexity of the interactions among cellular constituents and the quantity of data about these interactions hinders the ability to predict how cells will respond to perturbation and how they can be engineered for industrial or medical purposes. Models provide a systematic framework to describe and analyze these complex... Read More

Biomaterials for Craniofacial Bone Regeneration

Image Dentistry and Craniofacial Research is one of the best open access journals that aims to publish the most complete and reliable source of information on discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in this field and provide online access without any restrictions or subscriptions to researchers worldwide. Functional reconstruction of craniofacial defects is a major clinical challenge in craniofacial sciences. The advent of biomaterials is a potential alternative to standard autologous/allogenic grafting procedures to achieve clinically successful bone regeneration.  This article discusses various classes of biomaterials currently used in craniofacial... Read More

Three-dimensional craniofacial imaging

Image Dentistry and Craniofacial Research is one of the best open access journals that aims to publish the most complete and reliable source of information on discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in this field and provide online access without any restrictions or subscriptions to researchers worldwide. The clinical application of 3-dimensional craniofacial imaging is one of the most exciting and revolutionary topics in dentistry.  Cone-beam computed tomography (CBCT), also known as cone-beam volumetric tomography (CBVT), has followed the trend of computed tomography (CT) in medicine, in which, after the... Read More

The Parentified Child

Image Young carers are children under the age of 18 who provide care to a family member. Concern has been raised within the welfare services that these children are involved in levels and types of care that are developmentally inappropriate and that jeopardize their health and development. Despite a vast literature on the psychological impacts of caregiving upon adult carers, there has been little investigation into the impacts upon children. This review focuses on one main area of research that has examined children as caregivers; research on the ‘parentified child’. This literature derives from the traditions of systemic theory and is... Read More

Visions of infancy: A critical introduction to child psychology

Image This new textbook introduces students to the many different perspectives in child psychology by analysing what the major figures in the field have said about the mental life of babies. From the earlier writings of Darwin and Freud to the more recent contributions of Piaget, Skinner, Chomsky, Bowlby and others, Ben Bradley offers a clear appraisal of the origins, development and current concerns of the discipline of child psychology. The initial chapters deal in turn with Darwin's work on babies, with associationism and behaviourism, and with some of the major figures in psychoanalysis, including Freud, Klein and Lacan. The author... Read More

Biofertilizer from Waste Crab Shell Recycling for Aquaponics System

Image The biofertilizer, made of crab shell waste, was used as nutrients source in aquaponics system. The present study was carried out to assess the growth of watercress. The effluents from catfish culture tank were flown through aquaponic systems. The height of water cress and the length of root was increased more than two centimetres in 10 days for all experiments. The height and root length of water cress was differentafter15days. Biochemical oxygen demand (BOD5) was increased with biofertilizer due to organic matter from the biofertilizer. The results showed the potential of biofertilizer effects on the growth of... Read More

Rainwater recovery system

Image A system and method for restoring the natural water cycle by reducing stormwater runoff and addressing issues affecting groundwater supply. In one embodiment of the invention, the system comprises a roof washer component, cistern component, pump, and manufactured dry well. The system is designed to divert polluted rooftop runoff, capture clean rooftop runoff and store this clean water for irrigation purposes and nonpotable uses, while infiltrating excess water to recharge groundwater supplies thereby replicating the natural hydrologic cycle. CROSS-REFERENCE TO RELATED APPLICATIONS : The present application claims priority to U.S. Provisional Application No. 60/407,162, filed Aug. 30, 2002,... Read More

The Vital Role of Food Preservatives

Image The Vital Role of Food Preservatives Journal of Food and Clinical Nutrition is a peer reviewed open access journal. Here we have discussed about The Vital Role of Food Preservatives Definition Food preservatives play a vital role in preventing deterioration of food, protecting against spoilage from mold, yeast, life-threatening botulism and other organisms that can cause food poisoning. By extension, preservatives reduce food cost, improve convenience, lengthen shelf life and reduce food waste. Functions, Names and Labeling There are two modes of preservation: physical and chemical. Physical preservation refers to processes such as refrigeration or drying. Chemical preservation is adding ingredients... Read More

Trans fat relates to increases the risk for heart attacks, stroke and type 2 diabetes

Image Trans fat relates to increases the risk for heart attacks stroke and type 2 diabetes Journal of Food and Clinical Nutrition is a peer reviewed open access journal. Here we have discussed about Trans fat relates to increases the risk for heart attacks, stroke and type 2 diabetes. Trans fat increases your "bad" cholesterol and lowers your "good" cholesterol. Find out more about trans fat and how to avoid it. What is trans fat? Most trans fat is formed through an industrial process that adds hydrogen to vegetable oil, which causes the oil to become solid at room temperature. This partially... Read More

Environmental factors that may affect human reproductive health.

Image The Journal of Basic and Clinical Reproductive Sciences (JBCRS) is devoted to convey and spread to its researchers around the world, the latest knowledge in relation to the recent advances in the field of Reproductive Sciences. The journal includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises a peer review process for the submitted manuscripts for the quality of publishing. Aim is to catalogue the current scholarly information sourced from across the world and broadcast to maximize in reliable... Read More

Durable Long-Term Responses in B-cell Lymphoma and Chronic Lymphocytic Leukemia After Anti-CD19 CAR T-Cell Therapy

Image Long-term follow-up of the anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in patients with B-cell lymphoma and chronic lymphocytic leukemia (CLL) demonstrated highly durable remissions with few long-term adverse effects. These findings were presented by Kathryn Cappell, MD, PhD, of the National Cancer Institute, during the ASCO20 Virtual Scientific Program. Between 2009 and 2015, the investigators conducted the first clinical trial (ClinicalTrials.gov Identifier: NCT00924326) of anti-CD19 CAR T cells that showed responses against lymphoma. The CAR from that trial, FMC63-28Z, was subsequently developed as axicabtagene ciloleucel. In the original study, 43 patients were treated with anti-CD19 CAR T cells (46... Read More

Allogenic CAR-T Cell Therapy Shows High Response Rate for Patients with Relapsed/Refractory B-Cell Lymphomas

Image The allogeneic chimeric antigen receptor (CAR)-T cell therapy ALLO-501, paired with the monoclonal antibody ALLO-647, showed clinical activity and a manageable safety profile in patients with relapsed/refractory large B-cell or follicular lymphoma. The first-in-human findings were presented during the virtual scientific program of the American Society of Clinical Oncology (ASCO) 2020 Annual Meeting. The two treatments were used sequentially in the open-label, phase 1 ALPHA study that occurred across six U.S. sites, demonstrating an overall response rate of 63%, including a 37% complete response rate, in 19 evaluable, previously treated adults. Researchers believe that allogeneic CAR-T therapy, made from healthy... Read More

Clinical and Psychosocial Outcomes of Obstetrics Fistulae in Sub-Saharan Africa – A Review of Literature

Image Basic and Clinical Reproductive Sciences is an elite, highly cited, scientific open access journal that publishes peer reviewed, original research and review articles in the field of Reproductive science and medicine. The journal aims to publish recent advances in the research, development and applications of novel tools and techniques for the study of natural as well as assisted fertilization, implantation, and treatment of infertility. It encourages conceptual breakthroughs and clinical implications pertaining to the field of metabolomics of male and female reproduction, proteomics of male and female reproductive system, reproductive genetics, pathology & physiology of reproductive system,reproductive health, prenatal... Read More

Pharmacodynamics

Image Pharmacodynamics is the study of how drugs have effects on the body. The most common mechanism is by the interaction of the drug with tissue receptors located either in cell membranes or in the intracellular fluid. The extent of receptor activation, and the subsequent biological response, is related to the concentration of the activating drug (the 'agonist'). This relationship is described by the dose–response curve, which plots the drug dose (or concentration) against its effect. This important pharmacodynamic relationship can be influenced by patient factors (e.g. age, disease) and by the presence of other drugs that compete for binding at... Read More

Clinical pharmacokinetics

Image Pharmacokinetics can be simply described as the study of 'what the body does to the drug' and includes:  •    the rate and extent to which drugs are absorbed into the body and distributed to the body tissues •    the rate and pathways by which drugs are eliminated from the body by metabolism and excretion •    the relationship between time and plasma drug concentration. Understanding these processes is extremely important for prescribers because they form the basis on which the optimal dose regimen is chosen and explain the majority of the inter-individual variation in the... Read More

Lymphadenectomy

Image Lymphadenectomy or lymph node dissection is the surgical removal of one or more groups of lymph nodes. It is almost always performed as part of the surgical management of cancer. In a regional lymph node dissection, some of the lymph nodes in the tumor area are removed; in a radical lymph node dissection, most or all of the lymph nodes in the tumor area are removed. It is usually done because many types of cancer have a marked tendency to produce lymph node metastasis early in their natural history. This is particularly true of melanoma, head and... Read More

Lymph node biopsy

Image Lymph node biopsy is a test in which a lymph node or a piece of a lymph node is removed for examination under a microscope (see: biopsy). The lymphatic system is made up of several lymph nodes connected by lymph vessels. The nodes produce white blood cells (lymphocytes) that fight infections. When an infection is present, the lymph nodes swell, produce more white blood cells, and attempt to trap the organisms that are causing the infection. The lymph nodes also try to trap cancer cells. The test is used to help determine the cause of lymph node... Read More

Diet and exercise: Healthy Benefits

Image Diet and exercise: Healthy Benefits Journal of Food and Clinical Nutrition is a peer reviewed open access journal. It is a bimonthly journal. Here we have discussed about Diet and exercise: Healthy Benefits. Eating and exercise go hand in hand. When and what you eat can be important to how you feel when you exercise, whether it's a casual workout or training for a competition. Consider these eating and exercise tips. 1. Eat a healthy breakfast If you exercise in the morning, get up early enough to finish breakfast at least one hour before your workout. Be well fueled going into... Read More

Micronutrients and Types

Image Micronutrients and Types Journal of Food and Clinical Nutrition is a peer reviewed open access journal. It is a bimonthly journal. Here we have discussed about Role of Micronutrients and Types. Vitamins and minerals are the two types of micronutrients. While only needed in small amounts, they play important roles in human development and well-being, including the regulation of metabolism, heartbeat, cellular pH, and bone density. Lack of micronutrients can lead to stunted growth in children and increased risk for various diseases in adulthood. Without proper consumption of micronutrients, humans can suffer from diseases such as rickets (lack of vitamin D), scurvy (lack of... Read More

A human model to test implants for cataract surgery

Image A human model to test implants for cataract surgery Their latest human model allows evaluation of artificial intraocular lens (IOL) implants under conditions that better reflect the post-surgical environment. A cataract is a clouding of the eye's lens and affects millions worldwide. At present, the only way of treating cataract is with surgery and it is estimated that by 2020, more than 30 million such operations will be performed annually. During cataract surgery, the eye's cloudy natural lens is removed and replaced with an IOL. Initially, outcomes from cataract surgery are superb, but a haziness known as Posterior Capsule Opacification... Read More

Novel Anti-Tubercular Acylhydrazone Schiff Base Derivative study

Image Tuberculosis (TB) remains the most serious infectious disease worldwide and predominantly occurs in developing countries. The annual death from TB caused by Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR) Mycobacterium Tuberculosis (MTB) outnumbers Human Immunodeficiency Virus (HIV). Especially, 90% of active disease in MDR-TB occurs within the first two years and nearly all within three years, indicating the difficulties of MDR-TB treatment. The traditional anti-TB drugs such asisoniazid, rifampicin, pyrazinamide, ethambutol, streptomycin, kanamycin, amikacin, capreomycin, levofloxacin, ofloxacin have been widely used to treat TB at the doses recommended by the World Health Organization (WHO). However, previous studies suggested that, MDR-TB did... Read More

Association of Antinuclear Antibodies (ANA) Anti-NuMA1 and Anti-NuMA2 (Anti-HsEg5)

Image The prevalence of anti-NuMA1 and anti-NuMA2 antibodies in autoimmune, hepatic, infectious and renal inflammatory diseases is well known; however, its presence and possible relevance in cardiovascular diseases still needs to be elucidated. Aim: To evaluate the prevalence of positive anti-NuMA1 and anti-NuMA2 antibody patterns in subjects with autoimmune, non-autoimmune and/or cardiac diseases. Material and methods: This was an observational study run from January 2010 to January 2018. Individuals whose treating physician requested an antibody study and we detected anti NuMA1 and anti NuMA2 pattern in any patients. The files from these patients were reviewed to obtain general data, signs, symptoms,... Read More

Rare inflammatory disease, possibly tied to COVID-19, emerges in children

Image In what is now thought to be the first reported case of its kind, an infant with Kawasaki disease, a rare inflammatory disease affecting coronary arteries in children, also tested positive in March for COVID-19 — suggesting a possible connection between the two illnesses, Stanford Children's Health doctors have reported. Now, other medical experts in the country are finding a related and similar disease is emerging in children, despite the fact that most children with COVID-19 are generally asymptomatic or have mild to moderate symptoms. Physicians at Lucile Packard Children's Hospital Stanford reported the case of a 6-month-old girl who... Read More

Rady Re-Evaluating Recent Kawasaki Cases For New Pediatric Illness Tied To Coronavirus

Image San Diego's Children's Hospital is reviewing patients it recently treated for Kawasaki disease to determine if they were actually suffering from a similar but rare new illness connected to the novel coronavirus. Doctors around the world, often in regions hit hardest by the pandemic, have reported cases of a pediatric inflammatory illness that can affect multiple organs, including the heart. The condition is like Kawasaki disease, which causes inflammation of the blood vessels but is appearing in children who have had some form of exposure to the SARS-CoV-2 virus. Initially, the disease was dubbed pediatric inflammatory multisystem syndrome, or PIMS... Read More

Lymphatic filariasis

Image Lymphatic filariasis is a human disease caused by parasitic worms known as filarial worms. Most cases of the disease have no symptoms.Some people, however, develop a syndrome called elephantiasis, which is marked by severe swelling in the arms, legs, breasts, or genitals.The skin may become thicker as well, and the condition may become painful. The changes to the body have the potential to harm the person's social and economic situation. The worms are spread by the bites of infected mosquitoes.Three types of worms are known to cause the disease: Wuchereria bancrofti, Brugia malayi, and Brugia timori, with... Read More

Lymphangioleiomyomatosis

Image Lymphangioleiomyomatosis (LAM) is a rare, progressive and systemic disease that typically results in cystic lung destruction. It predominantly affects women, especially during childbearing years. The term sporadic LAM is used for patients with LAM not associated with tuberous sclerosis complex (TSC), while TSC-LAM refers to LAM that is associated with TSC. The average age of onset is the early to mid 30s.  Exertional dyspnea (shortness of breath) and spontaneous pneumothorax (lung collapse) have been reported as the initial presentation of the disease in 49% and 46% of patients, respectively. Diagnosis is typically delayed 5 to 6 years.The... Read More

Female Infertility

Image Infertility is defined as trying to get pregnant (with frequent intercourse) for at least a year with no success. Female infertility, male infertility or a combination of the two affects millions of couples in the United States. An estimated 10 to 18 percent of couples have trouble getting pregnant or having a successful delivery. Infertility results from female factors about one-third of the time and male factors about one-third of the time. The cause is either unknown or a combination of male and female factors in the remaining cases. Female infertility causes can be difficult to diagnose. There are many... Read More

Eyes send an unexpected signal to the brain: A subset of retinal neurons communicates differently from the rest of the eye

Image Eyes send an unexpected signal to the brain: A subset of retinal neurons communicates differently from the rest of the eye New research has found that a subset of retinal neurons sends inhibitory signals to the brain. Before, researchers believed the eye only sends excitatory signals. For decades, biology textbooks have stated that eyes communicate with the brain exclusively through one type of signaling pathway. But a new discovery shows that some retinal neurons take a road less traveled. New research, led by Northwestern University, has found that a subset of retinal neurons sends inhibitory signals to the brain.... Read More

Titrated Misoprostol Versus Dinoprostone for Labor Induction

Image Basic and Clinical Reproductive Sciences is an elite, highly cited, scientific open access journal that publishes peer reviewed, original research and review articles in the field of Reproductive science and medicine. The journal aims to publish recent advances in the research, development and applications of novel tools and techniques for the study of natural as well as assisted fertilization, implantation, and treatment of infertility. It encourages conceptual breakthroughs and clinical implications pertaining to the field of metabolomics of male and female reproduction, proteomics of male and female reproductive system, reproductive genetics, pathology & physiology of reproductive system,reproductive health, prenatal... Read More

Microarray analysis can provide quantitative gene expression information allowing for the generation of a molecular

Image Classification of cancers has been dominated by the fields of histology and histopathology which aim to leverage morphological markers for accurate identification of a tumour type. Histological methods rely on chemical staining of tissues with pigments such as haematoxylin and eosin and microscopy-based visualization by a pathologist. The identification of tumor subtypes is based on established classification schemes such as the International Classification of Diseases published by the World Health Organization which provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances, and external causes of injury or diseases. For some types of cancer, these methods are unable to distinguish between subclasses; for example, defining subgroups of diffuse... Read More

The ER-positive group could also be separated into three distinct subgroups

Image In a 2001 study published in the Proceedings of the National Academy of Sciences, further stratified the classifications described by Perou et al. and explored the clinical value of these breast cancer subtypes. The authors separated the ER-positive tumors into two distinct groups and found that tumor classification based on gene expression was related to patient survival. The expression of 427 genes was measured for 78 cancers and seven non-malignant breast samples. Following hierarchical clustering, the samples formed two groups at the highest level of organization reflecting the ER-positive and ER-negative phenotypes; the ER-negative cluster further stratified to groups identical... Read More

Hormones created by the kidney via the renin–angiotensin system, increasing risk of developing hypertension and heart failure

Image CKD is initially without symptoms, and is usually detected on routine screening blood work by either an increase in serum creatinine, or protein in the urine. As the kidney function decreases: Blood pressure is increased due to fluid overload and production of vasoactive hormones created by the kidney via the renin–angiotensin system, increasing risk of developing hypertension and heart failure. Urea accumulates, leading to azotemia and ultimately uremia (symptoms ranging from lethargy to pericarditis and encephalopathy). Due to its high systemic concentration, urea is excreted in eccrine sweat at high concentrations the and crystallizes on skin as the sweat evaporates ("uremic frost"). Potassium accumulates in the blood (hyperkalemia with a range of symptoms including malaise and potentially... Read More

Identification of preoperative risk factors for postoperative pulmonary complications

Image Identification of preoperative risk factors for postoperative pulmonary complications Postoperative pulmonary complications (PPC) are well-known after major thoracic and abdominal surgery and are associated with increased mortality, morbidity and prolonged hospital stay. There is no consensus in the literature regarding risk factors for PPC. To optimize care and prevent PPC, we aimed at identifying the most important preoperative risk factors. The Delphi method was used as a consensus-seeking approach. A total of 22 health professionals with clinical experience within the field of thoracic or abdominal surgery were invited to participate in the panel. Risk factors identified in the literature were... Read More

Angiotensin II receptor antagonists (ARBs) are generally first-line agents for blood pressure control

Image Chronic kidney disease (CKD) is a type of kidney disease in which there is gradual loss of kidney function over a period of months to years. Initially there are generally no symptoms; later, symptoms may include leg swelling, feeling tired, vomiting, loss of appetite, and confusion. Complications include an increased risk of heart disease, high blood pressure, bone disease, and anemia. Causes of chronic kidney disease include diabetes, high blood pressure, glomerulonephritis, and polycystic kidney disease. Risk factors include a family history of chronic kidney disease. Diagnosis is by blood tests to measure the estimated glomerular filtration rate (eGFR), and a urine test to measure albumin. Ultrasound or kidney biopsy may be performed to determine the underlying cause. Several severity-based staging systems are in use. Screening... Read More

Factors regulating axon regeneration via JNK MAP kinase in Caenorhabditis elegans

Image Axon regeneration following nerve injury is a highly conserved process in animals. The nematode Caenorhabditis elegans is an excellent model for investigating the molecular mechanisms of axon regeneration. Recent studies using C. elegans have shown that the c-Jun N-terminal kinase (JNK) plays the important role in axon regeneration. Furthermore, many factors have been identified that act upstream of the JNK cascade after axotomy. This review introduces these factors and describes their roles during the regulation of axon regeneration. Most neurons have long processes called axons, which send signals to adjacent neurons or muscles. A cut in the axon, due to... Read More

A novel dynein-type AAA+ protein with peroxisomal targeting signal type 2

Image Peroxisomal matrix proteins are imported into peroxisomes in a process mediated by peroxisomal targeting signal (PTS) type 1 and 2. The PTS2 proteins are imported into peroxisomes after binding with Pex7p. Niwa et al. (A newly isolated Pex7-binding, atypical PTS2 protein P7BP2 is a novel dynein-type AAA+ protein. J Biochem 2018;164:437–447) identified a novel Pex7p-binding protein in CHO cells and characterized the subcellular distribution and molecular properties of the human homologue, ‘P7BP2’. Interestingly, P7BP2 possesses PTS2 at the NH2 terminal and six putative AAA+ domains. Another group has suggested that the protein also possesses mitochondrial targeting signal at the NH2... Read More

An Audit of the Clinicopathological Spectrum of Benign Vascular Tumors of Female Genital Tract; with a Mini Narrative Review

Image Basic and Clinical Reproductive Sciences is an elite, highly cited, scientific open access journal that publishes peer reviewed, original research and review articles in the field of Reproductive science and medicine. The journal aims to publish recent advances in the research, development and applications of novel tools and techniques for the study of natural as well as assisted fertilization, implantation, and treatment of infertility. It encourages conceptual breakthroughs and clinical implications pertaining to the field of metabolomics of male and female reproduction, proteomics of male and female reproductive system, reproductive genetics, pathology & physiology of reproductive system,reproductive health, prenatal... Read More

Portal venous system

Image In the circulatory system of animals, a portal venous system occurs when a capillary bed pools into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the... Read More

Potential new treatment for severe dry eye disease

Image Potential new treatment for severe dry eye disease Scientists have discovered a potential new treatment for a disease that causes severe dry eyes and dry mouth. The study, led by researchers at RCSI University of Medicine and Health Sciences, is published in the current edition of Scientific Reports. The work was carried out in collaboration with the Royal Victoria Eye and Ear Hospital and the Cedars-Sinai Medical Centre. Sjogren's Syndrome causes a patient's white blood cells to attack the body's tear and saliva glands, causing severe dry eyes and mouth. The dry and irritated eyes significantly impact their vision,... Read More

Role of Flavonoids in Alzheimer’s and Parkinson’s

Image Role of Flavonoids in Alzheimer’s and Parkinson’s Journal of Food and Clinical Nutrition is a peer reviewed open access journal. It is a bimonthly journal. Here we have discussed about Role of Flavonoids in Alzheimer’s and Parkinson’s. Flavonoids are a group of antioxidant phytonutrients that, along with carotenoids, are responsible for the vivid colors in fruits and vegetables. Flavonoids also appear to contribute important health benefits. Which Foods Contain Flavonoids? There are more than 5,000 different Flavonoids in the plants we eat. Flavonoids are found in fruits, vegetables, nuts, and grains. They are plentiful in cocoa powder and, to a lesser extent, in other... Read More

Familial hypercholesterolemia- Symptoms, Causes and Treatment

Image Familial hypercholesterolemia- Symptoms, Causes and Treatment Journal of Food and Clinical Nutrition is a peer reviewed open access journal. It is a bimonthly journal. Here we have discussed about Familial hypercholesterolemia. Familial hypercholesterolemia affects the way the body processes cholesterol. As a result, people with familial hypercholesterolemia have a higher risk of heart disease and a greater risk of early heart attack. The gene that causes familial hypercholesterolemia is inherited. The condition is present from birth. Treatments including medications and healthy lifestyle behaviors can help reduce the risks. Symptoms High cholesterol is a common medical condition, but it's often the result... Read More

Obesity: Causes, Complications, and Diagnosis

Image Obesity: Causes, Complications, and Diagnosis Journal of Food and Clinical Nutrition is a peer reviewed open access journal. It is a bimonthly journal. Here we discuss about Obesity: Causes, Complications, and Diagnosis Obesity is a medical condition in which excess body fat has accumulated to an extent that it may have a negative effect on health. Causes Eating more calories than you burn in daily activity and exercise (on a long-term basis) causes obesity. Over time, these extra calories add up and cause you to gain weight. Common specific causes of obesity include: eating a poor diet of foods high in fats and calories having... Read More

Diet Review: Mediterranean Diet

Image Diet Review: Mediterranean Diet Journal of Food and Clinical Nutrition is a peer reviewed open access journal. It is a bimonthly journal. Chances are you have heard of the Mediterranean diet. If you have a chronic condition like heart disease or high blood pressure, your doctor may even have prescribed it to you. It is often promoted to decrease the risk of heart disease, depression, and dementia. The traditional diets of countries bordering the Mediterranean Sea differ slightly so there are different versions of the Mediterranean diet. However, in 1993 the Harvard School of Public Health, Old ways Preservation and Exchange... Read More

Recently 2020-Drugs Approval

Image Journal of Clinical Pharmacology and Toxicology is using Editorial Tracking System to maintain quality and transparency to the author in the peer-review process. Review processing will be performed by the editorial board members of the Journal of Clinical Pharmacology and Toxicology or by Reviewers (outside experts in the field). Two independent reviewer’s approval (Minimum reviewer’s approval) followed by editor approval is obligatory for acceptance of any manuscript excluding an editorial. 1) Zeposia (ozanimod) Capsules  Company: Bristol-Myers Squibb Company  Date of Approval: March 25, 2020  Treatment for: Multiple Sclerosis  Zeposia (ozanimod) is... Read More

Toxicology and Practice

Image Journal of Clinical Pharmacology and Toxicology is using Editorial Tracking System to maintain quality and transparency to the author in the peer-review process. Review processing will be performed by the editorial board members of the Journal of Clinical Pharmacology and Toxicology or by Reviewers (outside experts in the field). Two independent reviewer’s approval (Minimum reviewer’s approval) followed by editor approval is obligatory for acceptance of any manuscript excluding an editorial. We wish to bring together experts in the fields of technology and pharmacy practice to analyze how future innovations could change the ways in... Read More

Renovascular hypertension

Image Renovascular hypertension is a condition in which high blood pressure is caused by the kidneys' hormonal response to narrowing of the arteries supplying the kidneys. When functioning properly this hormonal axis regulates blood pressure. Due to low local blood flow, the kidneys mistakenly increase blood pressure of the entire circulatory system. It is a form of secondary hypertension - a form of hypertension whose cause is identifiable. The cause of renovascular hypertension is consistent with any narrowing/blockage of blood supply to the renal organ (renal artery stenosis). As a consequence of this action the renal organs release... Read More

The Application of First‑Trimester Volumetry in Predicting Pregnancy Complications

Image Basic and Clinical Reproductive Sciences is an elite, highly cited, scientific open access journal that publishes peer reviewed, original research and review articles in the field of Reproductive science and medicine. The Journal aims to render a global platform for scientists and academicians to discuss and share numerous developments and issues related to Reproductive science. The journal provides multi-disciplinary interpretation of the latest research advances in different aspects of basic and clinical reproductive science and medicine, including basic reproductive biology, maternal-foetal medicine, obstetrics, gynaecology, gestation, reproductive endocrinology, uro-gynaecology, and embryology as research articles, review articles, short communications, short reports, book... Read More

Researchers restore sight in mice by turning skin cells into light-sensing eye cells

Image Researchers restore sight in mice by turning skin cells into light-sensing eye cells Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors used for vision, sidestepping the need for stem cells. The lab-made rods enabled blind mice to detect light after the cells were transplanted into the animals' eyes. Researchers have discovered a technique for directly reprogramming skin cells into light-sensing rod photoreceptors used for vision. The lab-made rods enabled blind mice to detect light after the cells were transplanted into the animals' eyes. The work, funded by the National Eye Institute (NEI), published April... Read More

Advice on the use of point-of-care immunodiagnostic tests for COVID-19

Image In response to the growing COVID-19 pandemic and shortages of laboratory-based molecular testing capacity and reagents, multiple diagnostic test manufacturers have developed and begun selling rapid and easy-to-use devices to facilitate testing outside of laboratory settings. These simple test kits are based either on detection of proteins from the COVID-19 virus in respiratory samples (e.g. sputum, throat swab) or detection, in blood or serum, of human antibodies generated in response to infection. WHO applauds the efforts of test developers to innovate and respond to the needs of the population. However, before these tests can be recommended, they must be validated... Read More

Coronavirus disease (COVID-2019) R&D

Image The current COVID-19 pandemic is unprecedented, but the global response draws on the lessons learned from other disease outbreaks over the past several decades. As part of WHO’s response, the R&D Blueprint was activated to accelerate diagnostics, vaccines and therapeutics for this novel coronavirus. The Blueprint aims to improve coordination between scientists and global health professionals, accelerate the research and development process, and develop new norms and standards to learn from and improve upon the global response. On 30 January 2020, following the recommendations of the Emergency Committee, the WHO Director-General declared that the outbreak constitutes a Public Health Emergency... Read More

Let's Talk About the Causes of Lymphoma

Image Lymphoma is a cancer of the blood and the lymphatic system—part of your body’s germ-fighting setup that includes lymph nodes (like the ones in your neck that get swollen when you have a bad cold), the spleen, bone marrow, and an immune gland in the chest called the thymus. Lymphoma starts when infection-fighting white blood cells called lymphocytes mutate and start to grow out of control. There are two main categories of the disease. The first is known as Hodgkin’s lymphoma—also sometimes called “Hodgkin’s disease” and named after Thomas Hodgkin, the doctor who first described it in... Read More

Time Temperature Indicators (TTIs) in food packaging

Image Time Temperature Indicators (TTIs) in food packaging Journal of Food and Clinical Nutrition is a peer reviewed open access journal. It is a bimonthly journal. Effective management and control of the cold chain by application of Time Temperature Indicators (TTIs) in food packaging is a Review article which was published in volume 1 and issue 1 of our journal. Different temperature conditions cause unreliable printed shelf lives [best before dates] and food waste. As a result, in the EU, the percentage of food losses in food manufacturing is up to 39%, and a further 5% along the distribution chain. The United... Read More

Is Robotic is better than laparoscopic approach in rectal?

Image Is Robotic is better than laparoscopic approach in rectal? The treatment of rectal cancer is complex and responsible for sequelae due to the various therapeutic modalities, especially the surgical resection. The advent of minimally invasive surgery provided a faster postoperative recovery and a lower complication rate when compared to conventional surgery. The implementation of laparoscopic approach in rectal cancer was responsible for these better results, but the limitations of this method added to the development of robotics, raised the question of which minimally invasive method would be more advantageous in the approach of rectal cancer. Laparoscopic surgery offers the same... Read More

Salinity and hypertension of pregnant women in coastal regions of Bangladesh

Image Salinity and hypertension of pregnant women in coastal regions of Bangladesh Journal of Food and Clinical Nutrition is a peer reviewed open access journal. It is a bimonthly journal. Salinity and hypertension of pregnant women in coastal regions of Bangladesh is an editorial which was published in volume 1 and issue 1 of our journal. One of the most climatic changes effects in coastal Bangladesh is increasing drinking water salinity. About 45% salinity raised in these areas during the last seven decades. The intrusion of salt from the Bay of Bengal continuously contaminates the drinking water sources, such as rivers and... Read More

The Effect of Low‑Dose Ketamine (Preemptive Dose) on Postcesarean Section Pain Relief

Image Basic and Clinical Reproductive Sciences is an elite, highly cited, scientific open access journal that publishes peer reviewed, original research and review articles in the field of Reproductive science and medicine. The Journal aims to render a global platform for scientists and academicians to discuss and share numerous developments and issues related to Reproductive science. The journal provides multi-disciplinary interpretation of the latest research advances in different aspects of basic and clinical reproductive science and medicine, including basic reproductive biology, maternal-foetal medicine, obstetrics, gynaecology, gestation, reproductive endocrinology, uro-gynaecology, and embryology as research articles, review articles, short communications, short reports,... Read More

Pharmaceutical research: Drug Absorption

Image Absorption is the transfer of the drug into the bloodstream. In IV this process is complete thus the whole dose reaches the systemic circulation. However in other routes of administration the rate and efficiency is dependent on many factors and usually on ly results in partial absorption. Transport in GIT Due to their chemical properties, drugs are absorbed either by passive diffusion or active transport. Passive diffusion: Passive diffusion is facilitated by the concentration gradient accross the membrane. The drug moves from high concentration to low concentration, it does not require an extra carrier or extra energy. Water-soluble agents use aquaous... Read More

A Path of a New Vision: The Ophthalmologist: Clinical and Therapeutic Journal

Image A Path of a New Vision: The Ophthalmologist: Clinical and Therapeutic Journal The Ophthalmologist Clinical and Therapeutic Journal covers a broad spectrum of topics in clinical and laboratory studies in ophthalmology. The aim is to address current issues and challenges in field, gather the information from different perspectives, as well as encourage the novel and efficient therapeutic potentials for eye diseases. Through such various formats as: case series, reviews, guidelines, techniques, and practices, the journal discusses cutting-edge ideas in eye research and establishes a platform from which to share the technical and medical advancements in field. Our knowledge about... Read More

COVID-19 Vaccine "Largely Protected" Monkeys From Virus: Chinese Firm

Image Beijing: A novel coronavirus vaccine has for the first time "largely protected" monkeys from infection during an animal trial, data from a Chinese pharmaceutical giant showed. It is among a slew of vaccines being developed around the world as countries race to stop an outbreak that has infected around 2.7 million people globally and killed more than 190,000. Nasdaq-listed Sinovac Biotech said it injected two different doses of its vaccine into eight rhesus macaque monkeys and exposed them to the virus three weeks later, and they did not develop infections. All the monkeys "were largely protected against SARS-CoV-2 infection", Sinovac... Read More

Covid-19 vaccine: Oxford University to start human trials from today

Image Oxford University will start human testing with a Covid-19 vaccine they developed from Thursday, the UK government said in a coronavirus press conference. The Oxford team – led by Professor Sarah Gilbert, is testing ChAdOx1 nCoV-19, a candidate based on a chimpanzee adenovirus modified to include the spike or ‘S’ protein on the surface of SARS-CoV-2, the virus that causes Covid-19. The government funded the vaccine project with 20 million pounds to Oxford University and another 22 million pounds to a second vaccine project at Imperial College, London, Health Secretary Matt Hancock said on Wednesday, adding the project will help support phase 2 trials and... Read More

The association of proteinuria with increased later cancer risk is well documented

Image Journal of Molecular Cancer is an open access, peer reviewed, scholarly journal that aims to enhance our understanding on the genesis, diagnosis, consequences of cancer molecules by critiquing the literature on Molecular Cancer, Cell and Tumor Biology, Angiogenesis, Cancer Antigens, Cellular Signaling and Molecular Biology, Genetic And Molecular Profiling of Cancer, DNA Damage and Repair, Cell Cycle, Metastasis. When the amount of proteins excreted in the urine exceeds the liver's ability to compensate, fewer proteins are detected in the blood – in particular albumin, which makes up the majority of circulating proteins. The association of cancer with glomerulonephritis is... Read More

Inflammation that affects the cells surrounding the glomerulus, podocytes, increases the permeability to proteins

Image Journal of Kidney Treatment and Diagnosis is a peer-reviewed, Open Access journal focused on Clinical Nephrologypractice and related diseases.It covers several clinical areas of renal medicine, such as dialysis, transplantation, diabetes, anaemia, pharmacy nutrition and clinical aspects of kidney care. The nephrotic syndrome is characterised by the finding of edema in a person with increased protein in the urine and decreased protein in the blood, with increased fat in the blood. Inflammation that affects the cells surrounding the glomerulus, podocytes, increases the permeability to proteins, resulting in an increase in excreted proteins. When the amount of proteins excreted in the urine exceeds the... Read More

Diabetes| An Insulin deficiency Disorder

Image Diabetes| An Insulin deficiency Disorder Journal of Food and Clinical Nutrition is a peer reviewed open access journal. Diabetes mellitus, also called diabetes, is a term for several conditions involving how your body turns food into energy. When you eat a carbohydrate, your body turns it into a sugar called glucose and sends that to your bloodstream. Your pancreas releases insulin, a hormone that helps move glucose from your blood into your cells, which use it for energy. When you have diabetes and don’t get treatment, your body doesn’t use insulin like it should. Too much glucose stays in your blood, a... Read More

Antioxidants for health

Image Antioxidants for health Journal of Food and Clinical Nutrition is a peer reviewed open access journal. The release of a scientific journal is always something memorable since it is of fundamental importance for the dissemination of the scientific discoveries and of paramount importance for the advances in the researches. In this context, the Journal of Food and Clinical Nutrition aims to contribute to scientific development through the publication of research in the area. Increasingly, healthy food has gained prominence in recent years, in addition to nutritional aspects, research has been dedicated to discovering the possible positive effects of food on the... Read More

Lymph capillary

Image Journal of Phlebology and Lymphology (1983-8905) is a peer reviewed open access journal. This scientific journal aims to provide the most complete and reliable source of information on the current developments in the field of Phlebology and Lymphology. The emphasis will be on publishing quality papers rapidly and making them available to researchers worldwide at no cost. Journal of Phlebology and Lymphology is devoted entirely to function, mechanism, pathology of Lymphatic system and venous diseases. The journal keeps interventionalists, phlebologists, wound care specialists that treat acute, chronic and emergency wounds, and allied health professionals up-to-date by providing... Read More

Venous blood

Image Journal of Phlebology and Lymphology (1983-8905) is a peer reviewed open access journal. This scientific journal aims to provide the most complete and reliable source of information on the current developments in the field of Phlebology and Lymphology. The emphasis will be on publishing quality papers rapidly and making them available to researchers worldwide at no cost. Journal of Phlebology and Lymphology is devoted entirely to function, mechanism, pathology of Lymphatic system and venous diseases. The journal keeps interventionalists, phlebologists, wound care specialists that treat acute, chronic and emergency wounds, and allied health professionals up-to-date by providing... Read More

A Rare Presentation of Aggressive Angiomyxoma as a Cervical Polyp

Image Basic and Clinical Reproductive Sciences is an elite, highly cited, scientific open access journal that publishes peer reviewed, original research and review articles in the field of Reproductive science and medicine. The Journal aims to render a global platform for scientists and academicians to discuss and share numerous developments and issues related to Reproductive science. The journal provides multi-disciplinary interpretation of the latest research advances in different aspects of basic and clinical reproductive science and medicine, including basic reproductive biology, maternal-foetal medicine, obstetrics, gynaecology, gestation, reproductive endocrinology, uro-gynaecology, and embryology as research articles, review articles, short communications,... Read More

Combat COVID-19 Pandemic Together

Image Combat COVID-19 Pandemic Together The COVID-19 outbreak presents the unprecedented challenge for world public and medical practitioners and health care providers. The Ophthalmologist: Clinical and Therapeutic Journal of pulsus publisher is herein to participate the combating COVID-19 through all possible efforts, as a Clinical science publisher, we would facilitate the rapid and effective communication of management of this pandemic, we will consider submissions related to all aspects of this disease, including prevention, basic viral research, epidemiology, treatment, vaccine, fast screening, diagnosis, prognosis, etc. We will process such manuscripts in priority and publish them ASAP after peer-reviewed and accepted. The... Read More

Early New Drugs Approval

Image Journal of Clinical Pharmacology and Toxicology is using Editorial Tracking System to maintain quality and transparency to the author in the peer-review process. Review processing will be performed by the editorial board members of the Journal of Clinical Pharmacology and Toxicology or by Reviewers (outside experts in the field). Two independent reviewer’s approval (Minimum reviewer’s approval) followed by editor approval is obligatory for acceptance of any manuscript excluding an editorial. 1) Zeposia (ozanimod) Capsules  Company: Bristol-Myers Squibb Company  Date of Approval: March 25, 2020  Treatment for: Multiple Sclerosis  Zeposia (ozanimod) is... Read More

Coronaviruses found in two Indian bat species: ICMR study

Image As per a study by the Indian Council of Medical Research (ICMR), presence of a different kind of coronavirus has been found in two bat species in India. Researchers, however, said there is no evidence or research to claim that these bat coronaviruses can cause disease in humans. As the world grapples with coronavirus, researchers have found the presence of a different kind of coronavirus -- bat coronavirus (BtCoV) --in two bat species from Kerala, Himachal Pradesh, Puducherry and Tamil Nadu, according to a study by the Indian Council of Medical Research (ICMR). There is no evidence or research to... Read More

As COVID-19 forces world to quarantine, air quality has improved

Image As millions of people around the world quarantine in their homes to prevent the spread of COVID-19, research and photos show that quarantines appear to have made a positive, if unintended, impact on the environment. In February, air quality researches from NASA reported that there was a dramatic drop in nitrogen dioxide emissions coming from China, especially from Hubei province — the epicenter of the coronavirus pandemic. "This is the first time I have seen such a dramatic drop-off over such a wide area for a specific event," says Fei Liu, an air quality researcher at NASA's Goddard Space Flight... Read More

An Overview of Vulvovaginal Atrophy‑Related Sexual Dysfunction in Postmenopausal Women

Image Basic and Clinical Reproductive Sciences is an elite, highly cited, scientific open access journal that publishes peer reviewed, original research and review articles in the field of Reproductive science and medicine. The Journal aims to render a global platform for scientists and academicians to discuss and share numerous developments and issues related to Reproductive science. The journal provides multi-disciplinary interpretation of the latest research advances in different aspects of basic and clinical reproductive science and medicine, including basic reproductive biology, maternal-foetal medicine, obstetrics, gynaecology, gestation, reproductive endocrinology, uro-gynaecology, and embryology as research articles, review articles, short communications, short reports, book... Read More

Fiber consumption linked to lower breast cancer risk

Image Fiber consumption linked to lower breast cancer risk   Journal of Food and Clinical Nutrition is an international peer reviewed journal that publishes recent research developments made in the field of food science and nutrition biology. The journal provides an open access platform for the dissemination of the latest developments in the field of food and nutrition. The journal encompasses a broad range of topics that include multiple aspects of nutrition, dietetics and their application in clinical nutrition, sports nutrition and public health. The journal specifically prioritizes the manuscripts that may further the advent and application of medical... Read More

BASIC VIEW OF FOOD AND CLINICAL NUTRITION

Image        BASIC VIEW OF FOOD AND CLINICAL NUTRITION Journal of Food and Clinical Nutrition is a peer reviewed open access journal which announces articles for the upcoming issue of our journal Clinical nutrition is nutrition of patients in health care. Clinical in this sense refers to the management of patients, including not only outpatients at clinics, but also (and mainly) inpatients in hospitals. It incorporates primarily the scientific fields of nutrition and dietetics. It aims to keep a healthy energy balance in patients, as well as providing sufficient amounts other nutrients such as protein, vitamins, minerals. Dietary needs and disease processes Normally, individuals obtain the necessary nutrients their bodies require through normal... Read More

Pharmacy Toxicology and Practice

Image Journal of Clinical Pharmacology and Toxicology is using Editorial Tracking System to maintain quality and transparency to the author in the peer-review process. Review processing will be performed by the editorial board members of the Journal of Clinical Pharmacology and Toxicology or by Reviewers (outside experts in the field). Two independent reviewer’s approval (Minimum reviewer’s approval) followed by editor approval is obligatory for acceptance of any manuscript excluding an editorial. We wish to bring together experts in the fields of technology and pharmacy practice to analyze how future innovations could change the ways in... Read More

About The Ophthalmologist Clinical and Therapeutic Journal

Image About The Ophthalmologist Clinical and Therapeutic Journal The Ophthalmologist Clinical and Therapeutic Journal covers a broad spectrum of topics in clinical and laboratory studies in ophthalmology. The aim is to address current issues and challenges in field, gather the information from different perspectives, as well as encourage the novel and efficient therapeutic potentials for eye diseases. Through such various formats as: case series, reviews, guidelines, techniques, and practices, the journal discusses cutting-edge ideas in eye research and establishes a platform from which to share the technical and medical advancements in field. Our knowledge about how best to care for... Read More

Coronavirus: Chandigarh hospital plans plasma therapy trials to cure Covid-19 patients

Image HIGHLIGHTS PGIMER in Chandigarh is planning to conduct plasma trials to cure Covid-19 patients It is collaborating with another Covid-19 centre to launch plama trials PGIMER director Jagat Ram said plama therapy as Covid-19 cure holds promise The Post Graduate Institute of Medical Education and Research (PGIMER) in Chandigarh will soon launch trials for Plasma therapy for curing will test it in the COVID-19 patients. Dr Jagat Ram, Director, PGIMER, told India Today TV on Thursday that the institute will collaborate with another Covid-19 centre to launch the plasma therapy trials soon. "We have discussed this issue and... Read More

Journal of Biomolecules and Biochemistry: Volume 4 Issue 1| 2020

Image Journal of Biomolecules and Biochemistry is an open access, peer-reviewed journal that focuses on all aspects of Biomolecules and Biochemistry. Celebrating a successful publication history, PULJBB solicits research contributions pertaining to chemical, physical, mechanistic, and structural basis of biological or cell function, lipids, phospholipids, glycolipids, sterols, glycerolipids, carbohydrates, sugars, vitamins, hormones, neurotransmitters, metabolites, amino acids, nucleotides, monosaccharides, peptides, oligopeptides, polypeptides, proteins, nucleic acids, DNA, RNA, oligosaccharides, polysaccharides, glycoprotein, glycoconjugate, proteoglycan, cellulose, lignin and haemoglobin, and encompasses the fields of chemical biology, synthetic biology, disease biology, cell biology, nucleic acid biology, neuroscience, structural biology and biophysics. The Journal of... Read More

Too much sugar leads to early death, but not due to obesity

Image Too much sugar leads to early death, but not due to obesity Sugar-rich diets have a negative impact on health independent of obesity reports a new study led by the MRC London Institute of Medical Sciences, UK. Researchers discovered that the shortened survival of fruit flies fed a sugar-rich diet is not the result of their diabetic-like metabolic issues. The findings, published in the journal Cell Metabolism, instead suggest that early death from excess sugar is related to the build-up of a natural waste product, uric acid. We all know that consuming too much sugar is unhealthy. It increases our risk... Read More

N-Nitrosation of dimethylamine by Bacillus cereus isolated from fermented Palm sap (Elaeis guineensis)

Image N-Nitrosation of dimethylamine by Bacillus cereus isolated from fermented Palm sap (Elaeis guineensis)   Journal of Food and Clinical Nutrition is a peer reviewed journal that publishes recent research developments made in the field of food science and nutrition biology. The journal provides an open access platform for the dissemination of the latest developments in the field of food and nutrition. The journal encompasses a broad range of topics that include multiple aspects of nutrition, dietetics and their application in clinical nutrition, sports nutrition and public health. This study investigated the nitrosating activities of intact cells and cell fractions of Bacillus cereus isolated... Read More

Syndromes most commonly affect tissues which have not been invaded by the cancer

Image We are pleasure to introduce our Journal of Kidney Treatment and Diagnosis covers several clinical areas of renal medicine, such as dialysis, transplantation, diabetes, anaemia, pharmacy nutrition and clinical aspects of kidney care. Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. RCC is the most common type of kidney cancer in adults, responsible for approximately 90–95% of cases. Initial treatment is most commonly either partial or complete removal of the affected kidney(s). Where the cancer has not metastasised (spread... Read More

Pathogenesis involved in Lung cancer

Image  Lung carcinoma, is a malignant lung tumour characterized by uncontrolled cell growth in tissues of the lung. This growth can spread beyond the lung by the process of metastasis into nearby tissue or other parts of the body. Most cancers that start in the lung, known as primary lung cancers, are carcinomas. The two main types are small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC). The most common symptoms are coughing (including coughing up blood), weight loss, shortness of breath, and chest pains. The vast majority (85%) of cases of lung cancer are due to long-term tobacco smoking. About 10–15% of cases occur in people who have never smoked. These cases are often caused by a combination of genetic factors and exposure to radon gas, asbestos, second-hand smoke,... Read More

Drug Absorption : Pharmaceutical research

Image Absorption is the transfer of the drug into the bloodstream. In IV this process is complete thus the whole dose reaches the systemic circulation. However in other routes of administration the rate and efficiency is dependent on many factors and usually on ly results in partial absorption. Transport in GIT Due to their chemical properties, drugs are absorbed either by passive diffusion or active transport. Passive diffusion: Passive diffusion is facilitated by the concentration gradient accross the membrane. The drug moves from high concentration to low concentration, it does not require an extra carrier or extra energy. Water-soluble agents use aquaous... Read More

Carnivore diet analysis based on next‐generation sequencing: application to the leopard cat (Prionailurus bengalensis) in Pakistan

Image Diet analysis is a prerequisite to fully understand the biology of a species and the functioning of ecosystems. For carnivores, traditional diet analyses mostly rely upon the morphological identification of undigested remains in the faeces. Here, we developed a methodology for carnivore diet analyses based on the next‐generation sequencing. We applied this approach to the analysis of the vertebrate component of leopard cat diet in two ecologically distinct regions in northern Pakistan. Despite being a relatively common species with a wide distribution in Asia, little is known about this elusive predator. We analysed a total of 38 leopard cat faeces.... Read More

Next-generation sequencing technologies and applications for human genetic history and forensics

Image Determining the DNA sequence is the most comprehensive way of obtaining information about the genome of any living organism. For decades, Sanger sequencing [1] using fluorescently labeled terminating nucleotides and electrophoresis has been the gold standard sequencing technology. Sanger sequencing made an early impact in the field of microbial genomics, with the first complete bacterial genome, Haemophilus influenzae, sequenced in 1995.   Multicenter collaborations using numerous sequencing... Read More

Effects of atrazine and nitrate on northern leopard frog (Rana pipiens) larvae exposed in the laboratory from posthatch through metamorphosis

Image A ecent ecological rsk assessment of the herbicideatrazinefound that theecosystemsat greatest risk within North America are the streams, rivers, and reservoirs of the midwestern corn‐growing regions. Habitats adjacent to application areas could be exposed to high levels of atrazine during periods of amphibian activity such as breeding and migration. Because fertilizer application coincides both spatially and temporally with atrazine application in agricultural areas, we tested the effects of atrazine and nitrate on northern leopard frog (Rana pipiens) larvae in the laboratory. Larvae were exposed to atrazine (0, 20, and 200 μg/L) and nitrate (0, 5, and 30... Read More

Using energy budgets to combine ecology and toxicology in a mammalian sentinel species

Image   Ecotoxicological hazard assessment currently relies on a rather small number of standardized laboratory tests using species from different trophic levels (autotrophs, primary and secondary consumers). These standard tests measure apical toxicological endpoints such as lethality, and give emphasis to acute effects of high exposure concentrations   Limitations of this primarily descriptive approach are evident: on the one hand, apical endpoints provide little insight into the underlying toxic processes and mechanisms, which complicates grouping of chemicals on the basis of common modes of action, as well as effect extrapolation across species (Eggen... Read More

Dynamics and Endocytosis of Flot1 in Arabidopsis Require CPI1 Function

Image Membrane microdomains are nano-scale domains (10–200 nm) enriched in sterols and sphingolipids. They have many important biological functions, including vesicle transport, endocytosis, and pathogen invasion. A previous study reported that the membrane microdomain-associated protein Flotillin1 (Flot1) was involved in plant development in Arabidopsis thaliana; however, whether sterols affect the plant immunity conveyed by Flot1 is unknown.   Here, we showed that the root length in sterol-deficient cyclopropylsterol isomerase 1 (cpi1-1) mutants expressing Flot1 was significantly shorter than in control seedlings. The cotyledon epidermal cells in cpi1-1 mutants expressing Flot1 were smaller than in controls. Moreover, variable-angle total internal reflection... Read More

Functional Cyclization of Eukaryotic mRNAs

Image The closed-loop model of eukaryotic translation states that mRNA is circularized by a chain of the cap-eIF4E-eIF4G-poly(A)-binding protein (PABP)-poly(A) interactions that brings 5′ and 3′ ends together. This circularization is thought to promote the engagement of terminating ribosomes to a new round of translation at the same mRNA molecule, thus enhancing protein synthesis. Despite the general acceptance and the elegance of the hypothesis, it has never been proved experimentally.    Using continuous in situ monitoring of luciferase synthesis in a mammalian in vitro system, we show here that the rate of translation initiation at... Read More

Preventing Recurrent Miscarriage

Image Most recurrent miscarriages are caused by an abnormality in the embryo’s chromosomes. The mother’s age can be a factor, too, but there are steps you can take to increase your odds of a successful pregnancy Quit Smoking Smoking tobacco has been linked with reduced fertility in women and a higher risk of miscarriage, in which a pregnancy ends before the 20th week. It’s important to quit smoking before you try to conceive a baby. NYU Langone offers Tobacco Cessation Programs, which can give you the support you need. Limit Caffeine Although studies on caffeine’s role in miscarriage have had mixed... Read More

The Hoax of the Fight against Global Warming

Image Global warming is a hoax? Second US President Trump and his advisers the answer is yes. For the worldwide scientific majority warming it is real. For myself, instead, though it may seem impossible, due to the large amount of scientific personalities, political, technical, economic involved, the real hoax is the he actual fight against global warming, that global the institutional organs are carrying out, from before and after the Kyoto Protocol. In fact, there are detailed responsibilities, scientific, technical, economic and legislative, for the choices that have led to global warming, being wrong all the purification and power... Read More

Recycling and thermal treatment of MSW in a developing country

Image With the increase of the world population, urbanization and industrialization, the volume of generated municipal solid waste (MSW) has increased in an alarming rate and turned to be a challenge for public authorities. In recent years the world experienced the reflexes of the old bad practice of dumping MSW without any treatment and its negative impacts on the ecosystem. This led to continuous intensive and extensive efforts to provide feasible solutions before degrading completely our Planet.    One route is to divert MSW from landfills by recycling and incineration. Recycling economizes natural resources, water... Read More

Tunnel Vision and Symptoms

Image Tunnel Vision and Symptoms Tunnel Vision is quite a self-explanatory term, it is a condition when your eyes’ field of vision is narrowed down to an extent that you can’t see sideways like you used to prior to this condition, without turning your head sideways. That is why it is also referred as the ‘peripheral vision loss’ or ‘tunnel vision syndrome’, your inability to see through the outer edges of your visual field. You can either have a temporary tunnel vision or may become its victim permanently. Tunnel Vision Causes and Symptoms You can lose your peripheral vision... Read More

How to perform a lymphatic drainage massage

Image Lymphatic drainage massage is a form of gentle massage that encourages the movement of lymph fluids around the body. The fluid in the lymphatic system helps remove waste and toxins from the bodily tissues. Some health conditions can cause lymph fluid to build up. Lymphatic drainage massages can benefit people with lymphedema, fibromyalgia, and other conditions. While the heart continuously pumps blood through the blood vessels, the lymphatic system relies on the movement of smooth muscles to transport fluid through the lymph vessels. Health conditions can interrupt the normal flow of lymph, causing lymph fluid to build... Read More

WHO launches global megatrial of the four most promising coronavirus treatments

Image Could any of these drugs hold the key to saving coronavirus disease 2019 (COVID-19) patients from serious harm or death? On Friday, the World Health Organization (WHO) announced a large global trial, called SOLIDARITY, to find out whether any can treat infections with the new coronavirus for the dangerous respiratory disease. It’s an unprecedented effort—an all-out, coordinated push to collect robust scientific data rapidly during a pandemic. The study, which could include many thousands of patients in dozens of countries, has been designed to be as simple as possible so that even hospitals overwhelmed by an onslaught of COVID-19 patients... Read More

New coronavirus stable for hours on surfaces

Image The virus that causes coronavirus disease 2019 (COVID-19) is stable for several hours to days in aerosols and on surfaces, according to a new study from National Institutes of Health, CDC, UCLA and Princeton University scientists in The New England Journal of Medicine. The scientists found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was detectable in aerosols for up to three hours, up to four hours on copper, up to 24 hours on cardboard and up to two to three days on plastic and stainless steel. The results provide key information about the stability of SARS-CoV-2, which causes COVID-19 disease,... Read More

Retinal Detachment

Image Retinal Detachment Retinal detachment occurs when the retina becomes separated from the nerve tissues and blood supply underneath it. While painless, visually this has a clouding effect that has been likened to a gray curtain moving across the field of vision. Retinal detachment is a treatable condition, but it must be taken care of promptly, or it can cause vision loss and in the worst cases, blindness. What Causes Retinal Detachment? The retina is attached to the vitreous, the clear gel in the middle of our eye. As we age, the vitreous may shrink and sometimes during the... Read More

In-vivo study on rats to enhance recognizing the use of Anacyclus clavatus as traditional diet by the local population from TiziOuzou

Image In-vivo study on rats to enhance recognizing the use of Anacyclus clavatus as traditional diet by the local population from TiziOuzou Journal of Food and Clinical Nutrition is a peer reviewed journal that publishes recent research developments made in the field of food science and nutrition biology. The journal provides an open access platform for the dissemination of the latest developments in the field of food and nutrition. The journal encompasses a broad range of topics that include multiple aspects of nutrition, dietetics and their application in clinical nutrition, sports nutrition and public health. The journal specifically prioritizes... Read More

Journal of Food and Clinical Nutrition ||Membership Program

Image Journal of Food and Clinical Nutrition ||Membership Program Journal of Food and Clinical Nutrition is a peer reviewed journal that publishes recent research developments made in the field of food science and nutrition biology. The journal provides an open access platform for the dissemination of the latest developments in the field of food and nutrition. The journal encompasses a broad range of topics that include multiple aspects of nutrition, dietetics and their application in clinical nutrition, sports nutrition and public health. The journal specifically prioritizes the manuscripts that may further the advent and application of medical nutrition therapies for... Read More

Lymph node

Image A lymph node or lymph gland is an ovoid or kidney-shaped organ of the lymphatic system and the adaptive immune system. Lymph nodes are widely present throughout the body and are linked by the lymphatic vessels. They are major sites of B and T cells and other white blood cells. Lymph nodes are important for the proper functioning of the immune system, acting as filters for foreign particles and cancer cells, but they do not have a detoxification function. In the lymphatic system a lymph node is a secondary lymphoid organ. A lymph node is enclosed in... Read More

Systems biology approaches to the analysis of how the intracellular networks of normal cells are perturbed during carcinogenesis

Image We are pleasure to introduce our Journal of Molecular Cancer encourages researchers and gives more important for the manuscripts with updated information related to the journal. Our journal accepts papers in the form of protocols/research article/review/case report/mini-review/short commentary, etc. Cancer systems biology encompasses the application of systems biology approaches to cancer research, in order to study the disease as a complex adaptive system with emerging properties at multiple biological scales. Cancer systems biology represents the application of systems biology approaches to the analysis of how the intracellular networks of normal cells are perturbed during carcinogenesis to develop effective predictive models... Read More

The Ionization of Acidic Drug is Increased in Alkaline Urine and Ionized Drugs Cannot Easily Cross a Plasma Membrane

Image We are pleasure to introduce our Journal of Kidney Treatment and Diagnosis covers several clinical areas of renal medicine, such as dialysis, transplantation, diabetes, anaemia, pharmacy nutrition and clinical aspects of kidney care. Most diuretic drugs are either weak acids or weak bases. When urine is made alkaline, elimination of acidic drugs in the urine is increased. The converse applies for alkaline drugs. This method is only of therapeutic significance where the drug is excreted in active form in urine and where the pH of urine can be adjusted to levels above or below the pK value of... Read More

Self-assembling, donut-shaped nanoparticles form novel platform for development of new biomolecules

Image In work published recently in Nature Structural & Mechanical Biology, scientists at Fred Hutchinson Cancer Research Center described self-assembling, donut-shaped protein nanoparticles designed from scratch. The team showed that the nanoparticles, which can act as scaffolds for the organization and display of biomolecules currently used in various clinical and research applications, could someday enhance these applications by simplifying biomolecule production or by enabling scientists to introduce entirely new biomolecules. “We have developed a novel molecular scaffold that can display many copies of different types of cool proteins in a variety of numbers and... Read More

Researchers identify potential coronavirus vaccines and therapy targets

Image Researchers show that antibodies that can neutralize the virus that causes SARS can reduce how well the new coronavirus infects cells in laboratory studies. They also use an approved drug to reduce virus entry into cells. With global cases of COVID-19 surpassing 100,000, researchers are looking for ways to prevent new viral infections. The new coronavirus, called SARS-CoV-2, has strong similarities to other viruses in the coronavirus family, particularly those that cause SARS and MERS. Two new papers appeared recently in the journal Cell, investigating how SARS-CoV-2 infects cells. So, how exactly does the virus gain entry to cells, and why... Read More

Bioindicator

Image Journal of Pharmaceutical Microbiology be held by Imed Pub Publishing SL which is one of the leading international publishers of open access journals. We are overjoyed to promulgate that our Journal of Pharmaceutical Microbiology got outstretched for 5 volumes which is an enormous triumph on account of esteemed authors who made endowment to our journal more honored. A bioindicator is any species (an indicator species) or group of species whose function, population, or status can reveal the qualitative status of the environment. For example, copepods and other small water crustaceans... Read More

Structural biology: Toxicology

Image Structural biology is a branch of molecular biology, biochemistry, and biophysics concerned with the molecular structure of biological macromolecules (especially proteins, made up of amino acids, RNA or DNA, made up of nucleotides, membranes, made up of lipids) how they acquire the structures they have, and how alterations in their structures affect their function.This subject is of great interest to biologists because macromolecules carry out most of the functions of cells, and it is only by coiling into specific three-dimensional shapes that they are able to perform these functions. This architecture, the "tertiary structure" of molecules, depends in a complicated... Read More

Cervical Cancer in Women with Unhealthy Cervix

Image Basic and Clinical Reproductive Sciences is an elite, highly cited, scientific open access journal that publishes peer reviewed, original research and review articles in the field of Reproductive science and medicine. The Journal aims to render a global platform for scientists and academicians to discuss and share numerous developments and issues related to Reproductive science. The journal provides multi-disciplinary interpretation of the latest research advances in different aspects of basic and clinical reproductive science and medicine, including basic reproductive biology, maternal-foetal medicine, obstetrics, gynaecology, gestation, reproductive endocrinology, uro-gynaecology, and embryology as research articles, review articles, short communications, short reports,... Read More

Child Psychopathology

Image Journal of Child Psychology publishes articles on basic research and theory in the broad field of psychopathology and other abnormal behaviors, their determinants, and correlates. The following topics fall within the journal's major areas of focus: psychopathology — its etiology, development, symptomatology, and course normal processes in abnormal individuals Theoretical papers of scholarly substance on abnormality may be appropriate if they advance understanding of a specific issue directly relevant to abnormal psychology and fall within the length restrictions of a regular (not extended) article. Case Studies from either a clinical setting or a laboratory will be considered if... Read More

Penalty to Polluter Act: A Sustainable Solution to Reduce Extreme Pollution

Image The action of polluting especially by environmental contamination with man-made waste is pollution [1]. Polluters are those materials which are responsible for the decrease of quality of air, water, soil, noise and other natural environment. Polluter is a subject which is responsible for the pollution. Subject could be people, company/ organization, country, Industry/factory and any another subject. The study describes the polluter by separating into three types as follows; Product polluters: These are all polluters who produce first hand goods/ products and during the production they release waste materials (Pollutants) which makes environment polluted. It includes machines or engines that... Read More

Styrenics, Made for Recycling

Image In view of climate change, environmental pollution, population growth and the dependence on limited fossil resources, the transition from a linear economy to a closed-loop economy is both ecologically and economically necessary.  Currently, chemical recycling of plastics plays only a minor role. For example, in the year 2016, only 1.4 % of the plastic packaging wastes generated in Germany were chemically recycled, compared to 48.4% that were mechanically recycled [1]. Therefore, plastics recycling are mostly understood as mechanical recycling. Thermoplastic materials can easily be molten and reprocessed at elevated temperatures. In theory, this enables a re-use of the polymer at... Read More

Some Medicinal Plants with Anti-Fertility Potential: A Current Status

Image Journal of Basic and Clinical Reproductive Sciences is an International journal devoted to fostering research investigations. It is an Open Access, peer-reviewed, academic journal that provides a quality platform to publish the most complete and reliable source of information in the mode of original articles, review articles, case reports, short communications, etc. in all areas which are covered under the scope of the journal and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide. Journal of Basic and Clinical Reproductive Sciences stands among the best open access journals of scholarly publishing.  We... Read More

Understanding Hematology and Blood Disease Symptoms

Image Hematology is the study of diseases related to the blood, including diagnosis, pathology, treatment, prevention, and prognosis. There are a variety of diseases under the hematology umbrella—including anemia, bleeding disorders (hemophilia, blood clots, Von Willebrand disease), and blood cancers (leukemia, lymphoma, multiple myeloma). The blood is made up of different components, and different diseases of the blood are associated with these different components. Red Blood Cells Red blood cells transport fresh oxygen throughout your body. They are created in the bone marrow and have a typical lifespan of about four months. Red blood cell disorders include:... Read More

A Small Discussion about Psychological Eating

Image A Small Discussion about Psychological Eating The Journal of Food and Clinical Nutrition  covers a broad spectrum of topics for study that discusses theoretical and conceptual aspects of Food and Clinical Nutrition like Nutrition and Food Sciences, Food Biotechnology, Nutrition, Clinical Nutrition, Obesity and Weightloss, Food Safety, Nutrition and Diabetes, Potato Nutrition, Nutrigenomics, Molecular Nutrition and Malnourishment. Applied research with practical orientation on Hygiene, Human Development, Food Safety regulations and Human Nutrition are equally welcome. By making better food choices, you might be able to control compulsive eating behaviours and weight gain. You might also experience feelings... Read More

Cardiovascular Risk and Dietary Fibre

Image Cardiovascular Risk and Dietary Fibre Journal of Food and Clinical Nutrition is an international peer reviewed journal that publishes recent research developments made in the field of food science and nutrition biology. The journal provides an open access platform for the dissemination of the latest developments in the field of food and nutrition. Patients with type 1 and 2 diabetes have a higher risk of cardiovascular disease compared to non-diabetic populations. Improved dietary quality is essential to control risk factors and can prevent or delay cardiovascular disease in diabetic patients. Higher dietary fibre intake was inversely associated... Read More

Identification of Hepatitis C Virus Transmission Using a Next-Generation Sequencing Approach

Image Here, we describe a transmission event of hepatitis C virus (HCV) among injection drug users. Next-generation sequencing (NGS) was used to assess the intrahost viral genetic variation. Deep amplicon sequencing of HCV hypervariable region 1 allowed for a detailed analysis of the structure of the viral population. Establishment of the genetic relatedness between cases was accomplished by phylogenetic analysis. NGS is a powerful tool with applications in molecular epidemiology studies and outbreak investigations. Identification of HCV transmission is of critical importance in implementing measures aimed at preventing virus spread. HCV transmission networks are difficult to identify for several reasons. First,... Read More

History of wildlife toxicology

Image The field of wildlife toxicology can be traced to the late nineteenth and early twentieth centuries. Initial reports included unintentional poisoning of birds from ingestion of spent lead shot and predator control agents, alkali poisoning of waterbirds, and die-offs from maritime oil spills. With the advent of synthetic pesticides in the 1930s and 1940s, effects of DDT and other pesticides were investigated in free-ranging and captive wildlife. In response to research findings in the US and UK, and the publication of Silent Spring in 1962, public debate on the hazards of pollutants arose and national contaminant monitoring programs were initiated.  Shortly thereafter,... Read More

AUTOIMMUNE CIRRHOSIS

Image On behalf of the Journal of Immune Disorder and Therapy : Open Access, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we are privileged to welcome clinical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of immune disorder and therapy: Open Access. The Journal of Immune Disorder and Therapy : Open Access aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Cancer. The open access journal... Read More

AUTOIMMUNE OOPHORITIS

Image On behalf of the Journal of Immune Disorder and Therapy : Open Access, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we are privileged to welcome clinical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of immune disorder and therapy: Open Access. The Journal of Immune Disorder and Therapy : Open Access aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Cancer. The open access journal... Read More

Molecularly Targeted therapy is one of the major modalities of Medical Treatment

Image Targeted therapy or molecularly targeted therapy is one of the major modalities of medical treatment (pharmacotherapy) for cancer, others being hormonal therapy and cytotoxic chemotherapy. As a form of molecular medicine, targeted therapy blocks the growth of cancer cells by interfering with specific targeted molecules needed for carcinogenesis and tumor growth, rather than by simply interfering with all rapidly dividing cells (e.g. with traditional chemotherapy). Because most agents for targeted therapy are biopharmaceuticals, the term biologic therapy is sometimes synonymous with targeted therapy when used in the context of cancer therapy (and thus distinguished from chemotherapy, that is, cytotoxic therapy). However, the modalities can be combined; antibody-drug conjugates combine biologic and cytotoxic mechanisms into one targeted therapy. Another form of targeted therapy involves use of nano-engineered enzymes to... Read More

Evaluation of cannabinoid eye drops on five patients with intractable hypertensive open angle glaucoma

Image Evaluation of cannabinoid eye drops on five patients with intractable hypertensive open angle glaucoma The aim of the present work was the evaluation of a topic application of cannabinoids in 5 patients affected by late stage open angle glaucoma (OAG) in which both surgical and medical therapies had failed to decrease the intraocular pressure (IOP) to acceptable levels, and were not suitable to further surgical intervention. Eye drops were formulated with Bediol (containing low amounts of tetrahydrocannabinol [THC] and cannabidiol [CBD]), and with Bedrocan (containing higher amounts of THC and lower amounts of CBD). Patients were treated first with Bediol... Read More

Functions which were performed by kidney in our body

Image Journal of Kidney Treatment and Diagnosis consists of the latest findings related to pathogenesis and treatment of kidney disease, hypertension, acid-base and electrolyte disorders, dialysis therapies, and kidney transplantation. Case Reports highlight new diseases, and potential therapeutic strategies. Besides, Journal also publishes narrative reviews, editorials, and articles focusing on translational research, clinical practice, and socioeconomic aspects of kidney disease and treatment. Kidney disease affects millions of people in the United States, and there are just a few indicators that reveal issues with kidneys. Also, many people ignore early warning signs, while catching kidney disease early can mean... Read More

THE DARK MOLECULAR GAS

Image The mass of molecular gas in an interstellar cloud is often measured using line emission from low rotational levels of CO, which are sensitive to the CO mass, and then scaling to the assumed molecular hydrogen H2 mass. However, a significant H2 mass may lie outside the CO region, in the outer regions of the molecular cloud where the gas-phase carbon resides in C or C+. Here, H2 self-shields or is shielded by dust from UV photodissociation, whereas CO is photodissociated. This H2 gas is “dark” in molecular transitions because of the absence of CO and other trace molecules, and... Read More

Waste management by recycling of polymers with reinforcement of metal powder

Image Recycling of plastics/polymers is one of the waste management techniques which have been followed by many researchers. In past 20 years large number of applications in this field has been highlighted. But hither to very few have reported on plastic waste management by recycling of polymers with reinforcement of metal powder. In the present work an effort has been made to perform recycling of waste plastic/polymer with reinforcement of metal powder by controlling the melt flow index (MFI). The present study of recycling of waste plastic has been performed on single screw extruder machine by considering various input parameters (namely:... Read More

Tiny Blood Testing Device Can Detect Coronavirus At The Airport - Researchers Claim

Image Researchers at the AES Venture in Masdar City, Abu Dabhi, have developed a new device claiming that it would help in detecting viruses such as coronavirus just like a pregnancy or a diabetes sugar test. The company also claims that the detection could be done through a simple blood test which would be conducted on passengers at the UAE airport during arrival and that the results would be shared in real-time within a few minutes. The company has called the device ‘The Reader’ and stated that it has a mechanism to extract blood and share its findings with the health... Read More

Researchers identify potential coronavirus vaccine and therapy targets

Image Researchers show that antibodies that can neutralize the virus that causes SARS can reduce how well the new coronavirus infects cells in laboratory studies. They also use an approved drug to reduce virus entry into cells. The new coronavirus, SARS-CoV-2, is a type of virus called an enveloped RNA virus. This means that its genetic material is encoded in single-stranded RNA molecules surrounded by a cell membrane taken from the cell that it last infected. When enveloped viruses infect a cell, they do this using a two-stage process. The first step involves making a connection with a receptor on the... Read More

Dietary Fibre and Cardiovascular Risk in Diabetes Mellitus

Image Dietary Fibre and Cardiovascular Risk in Diabetes Mellitus The two main types of diabetes mellitus are diabetes type 1 (T1D) and diabetes type 2 (T2D). T2D is the most common form of diabetes mellitus. It accounts for 90% of the cases. The incidence of T2D increases by age. T2D is characterized by increased insulin resistance and decreased insulin sensitivity, as a result of obesity and physical inactivity, amplified by genetic susceptibility and advancing age. T1D accounts for 5-10% of the cases, and is usually diagnosed at a young age. T1D is characterized by complete β-cell destruction and no insulin production,... Read More

Overview on: Pharmacogenomics

Image Pharmacogenomics is the study of the role of the genome in drug response. Its name (pharmaco- + genomics) reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of an individual affects his/her response to drugs. It deals with the influence of acquired and inherited genetic variation on drug response in patients by correlating gene expression or single-nucleotide polymorphisms with pharmacokinetics (drug absorption, distribution, metabolism, and elimination) and pharmacodynamics (effects mediated through a drug's biological targets). The term pharmacogenomics is often used interchangeably with pharmacogenetics. Although both terms relate to drug response based on genetic influences, pharmacogenetics... Read More

Overview on: Pharmacovigilance

Image Pharmacovigilance (PV or PhV), also known as drug safety, is the pharmacological science relating to the collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. The etymological roots for the word "pharmacovigilance" are: pharmakon (Greek for drug) and vigilare (Latin for to keep watch). As such, pharmacovigilance heavily focuses on adverse drug reactions, or ADRs, which are defined as any response to a drug which is noxious and unintended, including lack of efficacy (the condition that this definition only applies with the doses normally used for the prophylaxis, diagnosis or therapy of disease, or for the modification... Read More

Budd–Chiari syndrome

Image Budd–Chiari syndrome is a very rare condition, affecting one in a million adults.[1] The condition is caused by occlusion of the hepatic veins that drain the liver. It presents with the classical triad of abdominal pain, ascites, and liver enlargement. The formation of a blood clot within the hepatic veins can lead to Budd–Chiari syndrome. The syndrome can be fulminant, acute, chronic, or asymptomatic. Subacute presentation is the most common form. Signs and symptoms The acute syndrome presents with rapidly progressive severe upper abdominal pain, yellow discoloration of the skin and whites of the... Read More

The Techniques of Molecular Biology to study Protein function is Molecular Cloning

Image One of the most basic techniques of molecular biology to study protein function is molecular cloning. In this technique, DNA coding for a protein of interest is cloned using polymerase chain reaction (PCR), and/or restriction enzymes into a plasmid (expression vector). A vector has 3 distinctive features: an origin of replication, a multiple cloning site (MCS), and a selective marker usually antibiotic resistance. Located upstream of the multiple cloning site are the promoter regions and the transcription start site which regulate the expression of cloned gene. This plasmid can be inserted into either bacterial or animal cells. Introducing DNA into bacterial cells can be done by transformation via uptake of naked DNA, conjugation via cell-cell contact or... Read More

The Kidney is almost synonymous with renal clearance or renal plasma clearance

Image Journal of Kidney Treatment and Diagnosis consists of the latest findings related to pathogenesis and treatment of kidney disease, hypertension, acid-base and electrolyte disorders, dialysis therapies, and kidney transplantation. Pharmacokinetics studies the manner and speed with which drugs and their metabolites are eliminated by the various excretory organs. This elimination will be proportional to the drug's plasmatic concentrations. In order to model these processes a working definition is required for some of the concepts related to excretion. The plasma half-life or half-life of elimination is the time required to eliminate 50% of the absorbed dose of a drug from... Read More

Pediatric Ophthalmology

Image Pediatric Ophthalmology Pediatric ophthalmology is a sub-speciality of ophthalmology concerned with eye diseases, visual development, and vision care in children. Eye problems in children Children experience a variety of eye problems, many quite distinct from adult eye diseases. Pediatric ophthalmologists are specially trained to manage the following disorders: Infections (Conjunctivitis). Strabismus is a misalignment of the eyes that affects 2-4% of the population; it is often associated with amblyopia. The inward turning gaze commonly referred to as "crossed-eyes" is an example of strabismus. The term strabismus applies to other types of misalignments, including an upward, downward, or outward... Read More

Obstetrics and Gynecology

Image Journal of Basic and Clinical Reproductive Sciences is an academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide. The journal selects the articles to be published with a single bind, peer review system, following the practices of good scholarly journals. It supports the open access policy of making scientific research accessible to one... Read More

Abnormal routine blood tests as predictors of mortality in acutely admitted patients

Image Background This study aimed to improve early risk stratification in the emergency department by creating a simple blood test score based on routine biomarkers and assess its predictive ability for 30-day mortality of acutely admitted patients. Methods This was a secondary analysis of data from the TRIAGE II study. It included unselected acutely admitted medical and surgical patients, who had albumin, C-reactive protein, creatinine, haemoglobin, leukocytes, potassium, sodium and thrombocytes levels analysed upon admission. Patients were classified according to the number of biomarker results outside the reference range into four risk groups termed “very low”, “low”, “intermediate”, and “high” with... Read More

Reference ranges of presepsin (soluble CD14 subtype) in term and preterm neonates without infection, in relation to gestational and postnatal age, in the first 28 days of life

Image Objective To determine the reference ranges of presepsin in term and preterm neonates without infection, with respect to gestational and postnatal age, within the first 28 days of life. Methods A total of 144 neonates born at 24–42 weeks’ gestation, including healthy term and preterm neonates without clinical signs or symptoms of infection, were included in this prospective observational study. Presepsin measurements included cord blood levels and serum levels on postnatal days 1, 3, 5, 7, 14, 21, and 28. Results The presepsin values corresponding to the 10th percentile ranged from 240.8 pg/mL (on day 1) to 129.9 pg/mL (on day 28), whereas those... Read More

Ginger Protects the Liver against the Toxic Effects of Xenobiotic Compounds

Image Ginger Protects the Liver against the Toxic Effects of Xenobiotic Compounds Ginger, the rhizomes of the plant Zingiber officinale Roscoe (Family Zingiberaceae), is arguably one of the most widely used culinary agent and spice in the world. In addition to its culinary use, ginger also possess medicinal properties, and has been used since antiquity to treat ailments like cold, headaches, nausea, stomach upset, diarrhea, digestive, gastrointestinal disturbances, rheumatic complaints, diarrhea, nausea, asthma and parasitic infections, arthritis and muscular discomfort in the various alternative and folk systems of medicine in the world. Phytochemical studies have shown that the unique culinary and... Read More

Menstrual cycle

Image Menstruation, or period, is normal vaginal bleeding that occurs as part of a woman's monthly cycle. Every month, your body prepares for pregnancy. If no pregnancy occurs, the uterus, or womb, sheds its lining. The menstrual blood is partly blood and partly tissue from inside the uterus. It passes out of the body through the vagina. It is a period happens because of changes in hormones in the body. Hormones are chemical messengers. The ovaries release the female hormones estrogen and progesterone . These hormones cause the lining of the uterus (or womb) to build up. Periods usually start between... Read More

Research on Biomolecules and Biochemistry: open access

Image Journal of Biomolecules and Biochemistry has announced almost 40% discount on article processing charges (APC) to commemorate its 3rd Anniversary. Editor-in-Chief Higo Nasser is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Journal of Biomolecules and Biochemistry is a web based, open-access, peer-reviewed broad scope journal covers the topics on chemical, physical, mechanistic, and structural basis of biological or cell function, lipids, phospholipids, glycolipids, sterols, glycerolipids, carbohydrates, sugars, vitamins,... Read More

Effect of Cooking Methods on Phenolic Compounds and Scavenging Activity of Cooked Mixed Grain Rice

Image Effect of Cooking Methods on Phenolic Compounds and Scavenging Activity of Cooked Mixed Grain Rice Recent studies have shown that thermally processed foods, especially fruits and vegetables, have higher biological activity due to changes in various compounds during heat treatment. The latest studies have reported that heat treatment increases total polyphenolic and flavonoid contents, and antioxidant activities in garlic, pears, tomatoes, oranges, and shiitake mushroom. Also, recent epidemiological studies have suggested that increased consumption of whole grains, fruits, and vegetables is associated with reduced risk of chronic diseases . This association might be attributed to natural antioxidants such as vitamin... Read More

Recovery Advantages of Transverse Skin

Image Recovery Advantages of Transverse Skin   General Surgery: Open Access is the newest contribution of Pulsus group towards the progress in medical science. Pulsus is a medical and healthcare publisher since 3 decades and received accolades from the contributors and the readers. At present, Pulsus Group is diversifying its publishing portfolio to other realms by incorporating all major Science, Technology, Medical journals as an ardent scientific publisher of open access and hybrid access peer reviewed journals. With a view to preserve, pursue, share and distribute scientific discoveries and knowledge, Pulsus health tech currently focusing... Read More

Preauricular lymph nodes: What to know

Image The preauricular lymph nodes sit just in front of the ears. These tiny nodes play a vital role in the immune system. What are the preauricular lymph nodes? The PLNs are a group of lymph nodes that sit just in front of the ears. These lymph nodes filter lymph fluid as it arrives from the scalp, neck, and various parts of the face. The human body contains about 600 small glands called lymph nodes that play an essential role in the function of the immune system. A network of vessels called the lymphatic system connects the lymph... Read More

IMMUNE-MODULATORY THERAPY

Image On behalf of the Journal of Immune Disorder and Therapy : Open Access, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we are privileged to welcome clinical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of immune disorder and therapy: Open Access. The Journal of Immune Disorder and Therapy : Open Access aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Cancer. The open access journal... Read More

CLINICAL IMMUNOLOGY and ALLERGIC DISEASES

Image On behalf of the Journal of Immune Disorder and Therapy : Open Access, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we are privileged to welcome clinical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of immune disorder and therapy: Open Access. The Journal of Immune Disorder and Therapy : Open Access aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Cancer. The open access journal... Read More

Pharmaceutical Technology-Open Access

Image Asian Journal of Pharmaceutical Technology and Innovation is a peer-reviewed, open access journal that reflects articles on all types of Drugs and Medicine. The journal welcomes submissions from all related fields of Pharmacy including advances in medicines. Articles will be also considered from related analysis from Drug Metabolism, Drug Delivery Systems, Drug Interactions, Drug Therapy, Drug Addiction, Pharmaceutical Industry, chemistry. Submission of important articles containing advanced research output aiding in forwarding the subject are most welcome. The wide scope of the journal will aid in contributing a great measure of scientific information related to the advances in towards better healthcare.... Read More

Proliferative Vitreoretinopathy: Diagnosis

Image Proliferative Vitreoretinopathy: Diagnosis  Proliferative vitreoretinopathy (PVR), a major complication of rhegmatogenous retinal detachment (RRD), is an abnormal process whereby proliferative, contractile cellular membranes form in the vitreous and on both sides of the retina, resulting in tractional retinal detachment with fixed retinal folds. Research suggests that membranes form in response to cytokines and inflammatory mediators that arise following anatomic disruption and tissue damage caused by rhegmatogenous retinal detachment (RRD) and resultant inflammation. Treatment is principally surgical and often requires multiple procedures that, in fact, yield a high rate of retinal reattachment; nevertheless, many anatomically successful eyes do not recover good... Read More

New Techniques involved in Discovery of Medicine for Cancer

Image Cancer occurs when a single progenitor cell accumulates mutations and other changes in the DNA, histones, and other biochemical compounds that make up the cell's genome. The cell genome controls the structure of the cell's biochemical components, the biochemical reactions that occur within the cell, and the biological interactions of that cell with other cells.About 70 percent of pharmaceuticals are manufactured using palladium-driven catalytic processes that are either fast or efficient - but not both. Researchers at North Carolina State University have now developed a green chemistry method that combines aspects of both processes to improve efficiency at a minimal cost of processing time.... Read More

Calcium is Excreted in to the Intestine via the Bile

Image Journal of Kidney Treatment and Diagnosis consists of the latest findings related to pathogenesis and treatment of kidney disease, hypertension, acid-base and electrolyte disorders, dialysis therapies, and kidney transplantation. Calcium metabolism is the movement and regulation of calcium ions (Ca2+) in (via the gut) and out (via the gut and kidneys) of the body, and between body compartments: the blood plasma, the extracellular and intracellular fluids, and bone. Bone acts as a calcium storage center for deposits and withdrawals as needed by the blood via continual bone remodeling. The plasma total calcium concentration is in the range of 2.2-2.6 mmol/L (9-10.5 mg/dL), and the normal ionized calcium is 1.3-1.5 mmol/L (4.5-5.6 mg/dL). The amount of total calcium in the blood varies with the level... Read More

Next-generation sequencing: recent applications to the analysis of colorectal cancer

Image Since the application of modern technology in medicine, scientists always tried to understand the real nature of nucleic acids. To this end, a great innovation was brought by the pioneer work of Sanger et al. in the late 70s, when they elaborated the most used method to sequence DNA [1], still considered as the gold standard in molecular diagnostics, even though it is expensive and time-consuming. Growing efforts have been made to widen technical knowledge in this field until the discovery of the “second and third-generation sequencing” methods [2, 3]. They are both part of the next-generation sequencing (NGS) technology,... Read More

Ecological risk assessment in the context of global climate change

Image Global climate change (GCC) is accepted increasingly within the scientific and regulatory communities and the informed public as capable of impacting human and ecological systems for centuries 1, 2. This report stems from a SETAC Pellston Workshop convened to assess the influence of GCC on the scientific foundations and applications of environmental toxicology and chemistry, specifically from the work group charged with determining how ecological risk assessment (ERA) needs to change to take into account GCC. Stahl et al. 3 provide a detailed account of the origins of the workshop and summarize the findings of other working groups. At its... Read More

Molecular Electronic Devices Based on Single-Walled Carbon Nanotube Electrodes

Image As the top-down fabrication techniques for silicon-based electronic materials have reached the scale of molecular lengths, researchers have been investigating nanostructured materials to build electronics from individual molecules. Researchers have directed extensive experimental and theoretical efforts toward building functional optoelectronic devices using individual organic molecules and fabricating metal−molecule junctions. Although this method has many advantages, its limitations lead to large disagreement between experimental and theoretical results. This Account describes a new method to create molecular electronic devices, covalently bridging a gap in a single-walled carbon nanotube (SWNT) with an electrically functional molecule. First, we introduce a molecular-scale gap into a... Read More

Practice of Waste Payment Collection from Public and the Improving of Its Challenges

Image In the ancient times too the municipal solid waste services were funded through flat rate billing, by surcharging on the local property tax that enforce beneficiaries to pay the same cost regardless of the quantity of solid waste generated and cost of disposal. The purpose of the municipal solid waste tariff strategy is to provide a framework and guidance for municipalities in setting solid waste tariffs that align with the intentions of the National Waste Management Strategy. The increased cost of landfilling, the dwindling landfill capacity the financial difficulties facing the municipalities, and the increasing environmental concern on the nation's... Read More

A Study of Next Generation Sequencing Data, Workflow, Application and Platform Comparison

Image DNA sequencing determines the precise order of nucleotides within a DNA molecule.Next generation Sequencing (NGS) is an efficient parallel high throughput DNA Sequencing Technology which revolutionizing the genomic research. Earlier methods that are quite expensive give rise to different sequence comparison techniques. NGS used for faster detection of variants in human genome and give rise to accelerated response to disease detection like cancer, hepatitis etc. In this paper work flow of data analysis part of NGS are clearly discussed. The different NGS platforms, its applications and different sequencing comparison techniques are also mentioned here. DNA Sequencing is a fundamental terminology... Read More

Environmental Health Status of Some Aquatic Ecosystems

Image Productivity and sustainability of water are usually known by the physicochemical properties of water quality. Due to indiscriminate release of wastes, physico-chemical characteristics of water do changes and this could cause hazard effect to flora and fauna of the aquatic ecosystem. Naturally, waters contain some impurities such as metals whose nature and amount vary with source. Some trace metals like copper, zinc, cobalt, iron, and manganese are essential nutrients to plants at very low concentrations. However, high concentrations of these metals are potential toxins to many biological systems. Reports have shown that high level of pollution with heavy metals result... Read More

Chromosomal Microarray Analysis Uncovers Pathogenic Copy Number Variations in Unexplained Neurodevelopmental Disorders and Congenital Anomalies

Image Background: Neurodevelopmental disorders represent a broad spectrum of cognitive, neurological, and/or psychiatric dysfunction caused by impairment of the brain during development. The present deals with the chromosomal rearrangements in patients with neurodevelopmental disorders, Developmental Delay/ Intellectual Disability (DD/ID) and/or congenital anomalies employing Chromosomal Microarray (CMA). Methods: We used the CytoScan_750k array platform (Affymetrix) to analyze 102 patients with unexplained neurodevelopmental disorders and congenital anomalies. In this process, we have identified several deleted or duplicated genes possibly underlying the DD/ID phenotype to correlate the genetics with the clinical data. Results: Of all the 102 patients identified with DD/ID, 48 patients had... Read More

The ‘mitochondrial contact site and cristae organising system’ (MICOS) in health and human disease

Image The ‘mitochondrial contact site and cristae organising system’ (MICOS) is an essential protein complex that promotes the formation, maintenance and stability of mitochondrial cristae. As such, loss of core MICOS components disrupts cristae structure and impairs mitochondrial function. Aberrant mitochondrial cristae morphology and diminished mitochondrial function is a pathological hallmark observed across many human diseases such as neurodegenerative conditions, obesity and diabetes mellitus, cardiomyopathy, and in muscular dystrophies and myopathies. While mitochondrial abnormalities are often an associated secondary effect to the pathological disease process, a direct role for the MICOS in health and human disease is emerging. This review describes... Read More

PINK1 import regulation at a crossroad of mitochondrial fate: the molecular mechanisms of PINK1 import

Image PTEN-induced kinase 1 (PINK1) is a mitochondrial kinase whose activity is tightly regulated by the mitochondrial health status. In response to mitochondrial damage, activated PINK1 can promote mitophagy, an autophagic elimination of damaged mitochondria, by cooperating with Parkin ubiquitin ligase. Loss-of-function of PINK1/Parkin-mediated mitophagy results in the accumulation of dysfunctional mitochondria, which could be one aetiology of Parkinson’s disease (PD). Within step-by-step signalling cascades of PINK1/Parkin-mediated mitophagy, mitochondrial damage-dependent PINK1 kinase activation is a critical step to trigger the mitophagy signal. Recent investigation of this process reveals that this stress-dependent PINK1 kinase activation is achieved by its regulated import into... Read More

Animations and Simulations for Teaching and Learning Molecular Chemistry

Image Animated visualizations that show both structures and processes help teachers convey important scientific concepts in chemistry and molecular biology. Designers of these animations benefit from knowing how students perceive and comprehend such visualizations. Specifically, instructional developers seek to design visualizations that allow students to learn critical concepts and relationships between these concepts. Students learn molecular chemistry concepts and relations by attending to, seeing, and understanding all the associated elements and the ways that they change and evolve during the process. Because often animations are too complex to be quickly understood, learners need to establish accurate mental models to assist in... Read More

WASTE MANAGEMENT INITIATIVES IN INDIA FOR HUMAN WELL BEING

Image “There are few things certain in life – one is death, second is change and the other is waste.” No one can stop these things to take place in our lives. But with better management we can prepare ourselves. Here we will talk about waste and waste management. Each of us has a right to clean air, water and food. This right can be fulfilled by maintaining a clear and healthy environment. Now for the first question, what is waste? Any material which is not needed by the owner, producer or processor is waste. Generally, waste is defined as at... Read More

Omega-3/6 Fatty Acids and Learning in Children and Young People

Image Omega-3/6 Fatty Acids and Learning in Children and Young People There is increasing evidence that nutritional insufficiencies, including that of omega-3 fatty acids can have adverse effects on brain development and neurodevelopment, thereby impacting on the ability to learn to and function sociably. It is well documented that humans once evolved on a diet providing a balanced 1:1 ratio of omega-6 to omega-3 fatty acids which is important for normal development throughout the life span. Yet Western diets now have a ratio of omega-6 to omega-3 of 10:1 up to 20-25:1 – a profile distinctly different to that on which... Read More

Behaviour of Child

Image                            Behaviour of Child  Journal of Child Psychology is an excellent source of information concerning all aspects of the development of children. It includes empirical psychological research on cognitive, social/emotional, and physical development. In addition, the journal periodically publishes Special Topic issues. Contributors are welcome to publish high quality clinical, and laboratory research papers, case series, reviews, guidelines, techniques, and practice manuscripts related to all aspects of emotional and intellectual well  being of children and adolescents. Author (s) may submit their manuscripts through online link https://www.pulsus.com/submissions/child-psychology.html or as an e-mail attachment childpsychol@scholarlypub.com... Read More

Developmental psychology

Image                            Developmental psychology The Journal of Child Psychology brings together the latest innovative research that advances knowledge of psychopathology from infancy through adolescence. The journal publishes studies that have a strong theoretical framework and use a diversity of methods, with an emphasis on empirical studies of the major forms of psychopathology found in childhood disorders (e.g., disruptive behavior disorders, depression, anxiety, and autism spectrum disorder). Studies focus on the epidemiology, etiology, assessment, treatment, prognosis, and developmental course of these forms of psychopathology. Studies highlighting risk and protective factors; the ecology and correlates of children's emotional, social, and behavior problems; and... Read More

Transforming Pharmaceutical Drug Discovery and Development- Recent Technological Advances

Image The last decade has seen rapid technological progress but with increasing demands for safe and efficacious drugs, technological solutions that reduce the barriers to clinical success will be of more interest than those that simply shift the bottlenecks and necessitate new compromises in the discovery and development process. Numerous problem areas remain: better information relative to disease pathophysiology is needed to improve target selection and validation; more predictive, biologically-relevant high throughput screens are essential; and, more emphasis must be placed on acquiring good ADME/Tox data earlier in the discovery process. Central to overcoming these barriers are innovative technologies generating high-value... Read More

A short on importance of appropriate nutritional therapy in hospitalized patients

Image A short on importance of appropriate nutritional therapy in hospitalized patients The appropriate nutrition of hospitalized patients has a direct effect on patient outcomes. Creating systems aimed at identifying patients at significant nutritional risk and monitoring adherence to evidenced based nutritional care practices have the potential to significantly improve outcomes and reduce costs. Patients who develop malnutrition represent a missed opportunity to deliver the critical nutrients needed and prevent the ramifications that come with a malnourished state. Despite increased calls for better nutritional screening, 1 in 3 patients who present to a hospital already meet the criteria for malnutrition. Malnutrition... Read More

To be a medicine or a toxin? this is a question – a sphingolipid story

Image From being a medicine to be a toxin there is a step. This is true for many aspects: from the structure, to the effect and to the dosage. For example, myriocin (ISP-1), a potent immunosuppressant, is an analog of sphingosine, and an inhibitor of the enzyme serine palmitoyl transferase that generates sphingosine. However, when it comes to the physiological effect, myriocin inhibits the growth of a mouse cytotoxic T lymphocyte line whereas sphingosine completely suppresses the inhibitory effect. But while you may think sphingosine is “good”, and that more is better, high doses of sphingosine start inhibiting protein kinase C... Read More

Nanomedicine and biological microenvironment monitoring

Image Nanomedicine have gained increasing attention in recent years. Compared to small molecules, nanoparticles have many advantages in biomedical applications such as controlled drug delivery and therapy (by taking advantage of EPR effect). As a collection of atoms/molecules, nanoparticles exhibit much stronger absorbance and emissions compared to small molecular probes, which can provide improved local contrast in biological imaging and sensing applications. However, the toxicity of nanoparticles is a concern for clinical application. Nano systems that can simultaneously combine diagnosis, therapy, and toxicity evaluation would be highly promising for future clinical applications. Monitoring of biological microenvironment can provide valuable information for... Read More

Lenitive Effects of Antioxidants in Noise Stress

Image Lenitive Effects of Antioxidants in Noise Stress Stress refers to a non-specific response of the body to unpleasant stimuli, threatening homeostasis and the integrity of the organism. It is a state of threatened homeostasis provoked by psychological, physiological and environmental stressors. Noise is measured in decibel (dB) units reported that noise exposure is a potent stressor as it increases the levels of the stress hormone, corticosterone. Noise pollution, especially in the urban environment, is on the increase and ranks among the environmental stressors with the highest public health impact. The auditory effects include hearing impairment and permanent hearing loss due... Read More

Journal of Health Policy and Management Invites Active Reviewers

Image Journal of Health Policy and Management Invites Active Reviewers Journal of Health Policy & Management is an open access scholarly periodical that publishes peer-reviewed scientific manuscripts based on update scientific revelations pertaining to multiple aspects of leadership, management and administration of public health systems, health care systems, hospitals and hospital networks. It brings together individual specialties from different fields, notably health management/policy/economics, epidemiology, social/public policy and philosophy into a dynamic academic mix. The journal also focusses on research areas such as Decision Science, Health Economics, Health Care Management and Public Health Policy. Now the ... Read More

Gestation and Parturition

Image Gestation Gestation is the period of development during the carrying of an embryo, fetus, or reptilian embryo inside viviparous animals. It is typical for mammals, but also occurs for some non-mammals. Mammals during pregnancy can have one or more gestations at the same time, for example in a multiple birth. The time interval of a gestation is called the gestation period. In human obstetrics, gestational age refers to the fertilization age plus two weeks. This is approximately the duration since the woman's last menstrual period began. Human pregnancy can be divided roughly into three trimesters, each approximately three months... Read More

Exercises using leisure resources to reduce arm lymphedema

Image Lymphedema is characterized by a type of edema caused by the abnormal accumulation of fluid and other substances in tissues resulting from a failure of the lymphatic drainage system, together with insufficient extralymphatic proteolysis of the cell interstitium and mobilization of macromolecules. Lymphedema can cause a high degree of dysfunction including decreased joint mobility with a reduced range of movements due, in part, to the weight of the limb and pain causing difficulty or even inability to perform daily tasks. Additionally, the psychological condition of the patient is impaired from the moment of breaking the news about... Read More

Intermittent occupational-related lymphedema

Image Chronic lymphedema is a progressive and a relatively painless swelling of any peripheral tissue – limbs, head and neck, breast, trunk or genitals that is the result of a lessthan-optimal transport capacity of the lymphatic system. Regarding the diagnosis of lymphedema, the patient’s history and physical examination were established as of fundamental importance. About complementary diagnostic clinic the Lymphoscintigraphy as part of the initial recommendation in cases of diagnostic doubt. Doppler ultrasound in the initial investigation but when there was suspicion of lymphedema secondary to tumor and Genetic testing in familial lymphedema. The conservative treatment is the... Read More

A RARE EYE DISEASE: PAPILLEDEMA

Image A RARE EYE DISEASE: PAPILLEDEMA Introduction Papilledema or papilloedema is optic disc swelling that is caused by increased intracranial pressure due to any cause. The swelling is usually bilateral and can occur over a period of hours to weeks. Unilateral presentation is extremely rare. Often, it's a warning sign of a serious medical condition that needs attention, such as a brain tumor or haemorrhage. But sometimes the pressure and swelling can't be traced to a specific problem. In that case, there are other ways to ease the swelling. Causes The main reasons for this disease may be a... Read More

The Era of Genome Editing

Image Gene or genome editing technologies are the hot trend in scientific community. There are several relative technologies which allow scientists not only to change precisely specific DNA sequences but also to change the regulation of gene expression in a well-defined region of the genome and in a specific way at the same time. This approach has thus far allowed the precise modification of genome sequences but it will probably prove to be a new tool for the discovery of novel functions of the genome. As it happened before, the arrival and the publications from the genome editing technologies raised the... Read More

Ecological Assessment for Trace Metal Pollution in a Freshwater Ecosystem

Image Heavy metals in the aquatic environment is of great ecological importance; hence, the study was carried out to evaluate the presence and effects of heavy metals on the water column, fish and sediment composition of Anambra River in July, 2011 and February, 2012 which covered both wet and dry season. The results of the physico- chemical properties showed significant variations (P<0.05) which occurred in DO and conductivity over the sampling seasons on different locations. pH, temperature and salinity showed seasonal difference at P<0.05 in different locations studied. There was no seasonal difference at P>0.05 among the heavy metal concentrations detected... Read More

Progenitor Carcinoma Stem Cell can be formed from Oncogenic Combinations of Mutations in a Totipotent Cell

Image Cancer occurs when a single progenitor cell accumulates mutations and other changes in the DNA, histones, and other biochemical compounds that make up the cell's genome. The cell genome controls the structure of the cell's biochemical components, the biochemical reactions that occur within the cell, and the biological interactions of that cell with other cells. Certain combinations of mutations in the given progenitor cell ultimately result in that cell (also called a cancer stem cell) displaying a number of abnormal, malignant cellular properties that, when taken together, are considered characteristic of cancer, including: the ability to continue to divide perpetually, producing an exponentially... Read More

Procedure involved in Laser lithotripsy

Image Laser lithotripsy is a surgical procedure to remove stones from urinary tract, i.e., kidney, ureter, bladder,or urethra. A urologist inserts a scope into the urinary tract to locate the stone. The scope may be a cystoscope, renoscope or nephroscope. An optical fiber is inserted through the working channel of the scope, and laser light is directly emitted to the stone. The stone is fragmented and the remaining pieces are collected in a "basket" and/or washed out of the urinary tract, along with the finer particulate "dust." The procedure is done under either local or general anesthesia and is considered a minimally-invasive procedure. It is widely available in most hospitals in the world. A urologist inserts a scope... Read More

Bioinformatics Approaches to the Understanding of Molecular Mechanisms in Antimicrobial Resistance

Image Antimicrobial resistance (AMR) is a major health concern worldwide. A better understanding of the underlying molecular mechanisms is needed. Advances in whole genome sequencing and other high-throughput unbiased instrumental technologies to study the molecular pathogenicity of infectious diseases enable the accumulation of large amounts of data that are amenable to bioinformatic analysis and the discovery of new signatures of AMR. In this work, we review representative methods published in the past five years to define major approaches developed to-date in the understanding of AMR mechanisms. Advantages and limitations for applications of these methods in clinical laboratory testing and... Read More

Journal of Biomolecules and Biochemistry: Open Access

Image Journal of Biomolecules and Biochemistry is an open access peer-reviewed broad scope journal publishes original articles, reviews, commentaries, short communications, case reports, editorials, letter to editor and Perspective articles.  Our aim is to encourage scientists to publish their latest experiments on major topics like biological chemistry, small molecules, monomers, polymers, biochemistry, cellular biosciences and molecular biology. Journal mainly focusing on biogenic substances and their biological structures, functions, interactions with other molecules, and their microenvironment as well as biological systems. The Journal is available both electronically and in print. The digital version is sent to more than 6,000 qualified researchers around the world. Each... Read More

Journal of Biomolecules and Biochemistry-Long Journey by Announcing Discounts on Article Processing Charges

Image Journal of Biomolecules and Biochemistry is an open access peer-reviewed broad scope journal publishes original articles, reviews, commentaries, short communications, case reports, editorials, letter to editor and Perspective articles.  Our aim is to encourage scientists to publish their latest experiments on major topics like biological chemistry, small molecules, monomers, polymers, biochemistry, cellular biosciences and molecular biology. Journal mainly focusing on biogenic substances and their biological structures, functions, interactions with other molecules, and their microenvironment as well as biological systems. The Journal is available both electronically and in print. The digital version is sent to more than 6,000 qualified researchers around the world. Each... Read More

Bioremediation Efficiency of Saccharomyces cerevisiae on Cadmium and Lead from Groundwater Obtained from Mining Community

Image Water is a vital requirement for life and it is also an effective vehicle for the transmission of diseases if contaminated.Pollution caused by heavy metals is one of the major environmental problems that are imperative to be solved. Mining of solid minerals has been identified as an entry point of heavy metals into the environment consequently polluting various components of the environment such as soil and water. Bioremediation offers a promising means to reclaim such contaminated environment in an economical and eco friendly way.The focus of this study is to evaluate the biosorption efficiency of cadmium and lead-resistant yeast from... Read More

VIROLOGY AND INFECTION DISEASES

Image On behalf of the Journal of Immune Disorder and Therapy : Open Access, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we are privileged to welcome clinical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of immune disorder and therapy: Open Access. The Journal of Immune Disorder and Therapy : Open Access aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Cancer. The open access journal... Read More

IMMUNE DISORDERS AND VACCINES

Image On behalf of the Journal of Immune Disorder and Therapy : Open Access, as Editor-in-Chief, it is my distinct honour and privilege to inform you that, we are privileged to welcome clinical Society to our journal. As Editor-In-Chief it is my great pleasure and honour to welcome you to the Journal of immune disorder and therapy: Open Access. The Journal of Immune Disorder and Therapy : Open Access aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to Cancer. The open access journal... Read More

The Ecology of Intertidal Gastropods

Image   The structure and dynamics of biological communities cannot be understood without considerable background information about the ecology of the component species. Experimental manipulations of natural populations in field situations are often the most profitable method of determining the factors that affect the distribution and abundance of species. Intertidal organisms have proved to be suitable for such direct experimentation because of the ease of access to intertidal areas, the relatively sessile nature, and due to the great abundance of many of the organisms. The chapter elaborates the key observations made on the ecology of intertidal gastropods such as the factors... Read More

Protein Sequence Analysis

Image Determination of amino acid sequence of protein, the study of the conformation changes of proteins and also the study of the complex molecules with any other non-peptide molecule is protein sequence analysis. The cellular processes of a living organism are known by the discovery of the structure and function of proteins, thus allowing researcher to develop and design drug targets. Mass-spectrometry and Edman degradation are the major methods to determine the protein sequencing. They have a principle advantage by following expansive quantities of proteins in parallel, which are additionally quick, mechanized, practical, profoundly touchy, and sparing examples and reagents. At... Read More

Asian Journal of Pharmaceutical Tecchnology and Innovation-Long Journey by Announcing Discounts on Article Processing Charges

Image The editorial team of Asian Journal of Pharmaceutical Technology and Innovation is overwhelmed by the response and eagerness of the academic and research contributors to publish with the journal and take part in the year-long celebrations. During this year we look forward to taking some initiates that would encourage and reward our prospective customers. It gives us great pleasure in announcing the call for paper on the 7th Anniversary of the Journal at special and hefty discount of up to 20 percent on one-time article processing charge. Prospective academicians and scientists are encouraged to utilize this opportunity to get their contents... Read More

Molecular Basis and Engineering of Enzymes Stereospecificity

Image Molecular recognition, particularly enantiomeric specificity of biological molecules is a key consideration in designing drugs, pharmaceutical intermediate and in industrial production of chirally active intermediate. Although the molecular bases of many enzymes stereospecificity are not completely delineated, a number of protein engineering studies were able to enhance and even in some cases invert the stereospecificity of various enzymes. Herein, we review the current understanding on enzymes stereospecificity, and the effects of mutations to the stereospecific pockets due to enzymes engineering to improve stereospecificity. Determining the molecular basis for stereospecificity of an enzyme requires the identification of the reacting orientations for... Read More

Recovery of Precious Metals Using Microalgae Waste

Image From waste residue of microalgae after extracting biofuel, some novel adsorption gels were prepared for the recovery of precious metals such as gold, palladium and platinum. The adsorption gel for gold was prepared in a simple manner by treating in boiling concentrated sulfuric acid.  Although the feed material, the microalgae waste itself, was found to selectively adsorb gold(III), palladium(II) and platinum(IV) from hydrochloric acid solution over base metals such as copper(II), nickel(II) and so on, the adsorption of gold(III) was dramatically enhanced by the treatment using boiling concentrated sulfuric acid; it was recovered as metallic gold particles. In order to... Read More

Health workforce

Image  The Health Workforce is a part of the Health Resources and Services Administration (HRSA), of the United States Department of Health and Human Services. HRSA programs train health care professionals and place them where they are needed most. Grants support scholarship and loan repayment programs at colleges and universities to meet critical workforce shortages and promote diversity within the health professions. Key Facts HRSA closely tracks trends in the national healthcare workforce, and issues targeted grants to colleges and universities for scholarship, student loan and debt repayment programs designed to stimulate interest in clinical specialties in which... Read More

The impact of next-generation sequencing technology on preimplantation genetic diagnosis and screening

Image Largely because of efforts required to complete the Human Genome Project, DNA sequencing has undergone a steady transformation with still-ongoing developments of high-throughput sequencing machines for which the cost per reaction is falling drastically. Similarly, the fast-changing landscape of reproductive technologies has been improved by genetic approaches. Preimplantation genetic diagnosis and screening were established more than two decades ago for selecting genetically normal embryos to avoid inherited diseases and to give the highest potential to achieve stable pregnancies. Most recent additions to the IVF practices (blastocyst/trophectoderm biopsy, embryo vitrification) and adoption of new genetics tools such as array comparative genome... Read More

Assessing the ecology in ecotoxicology: a review and synthesis in freshwater systems

Image The field of ecotoxicology is experiencing a surge in attention among ecologists as we gain a deeper appreciation for how contaminants can impact natural ecosystems. This interest is particularly strong in aquatic systems where many non‐target organisms experience pesticides. In this article, we assess how pesticides affect freshwater systems by applying the conceptual framework of density‐ and trait‐mediated indirect effects from the field of basic ecology. We demonstrate the utility of this framework for understanding the conditions under which pesticides affect species interactions, communities and ecosystems. Through the integration of laboratory toxicity tests and this ecological framework, ecotoxicologists should be... Read More

Risk Factors Involved in Oncology

Image   Journal of Molecular Cancer  is an Open Access academic peer-reviewed journal, aimed at worldwide dissemination of scientific research in the field of Cancer. We are truly obliged to introduce our Journal as we are looking forward to framing up an outstanding inaugural issue with best quality research articles for great impact among the readers globally. Tobacco- The leading cause of cancer, and death from cancer. Smoking is associated with increased risk of cancers of the lung, larynx, mouth, oesophagus, throat, bladder, kidney, liver, stomach, pancreas, colon, rectum, cervix and acute myeloid leukemia. Smokeless tobacco (snuff or chewing tobacco) is associated with increased risks of cancers of the mouth, oesophagus,... Read More

Streamlined process opens drug development to a new class of steroids.

Image Researchers at Dartmouth College have developed a technique to produce synthetic steroids that could pave the way for a cascade of new drug discoveries. The process facilitates access to rare, mirror-image isomers of naturally occurring steroid structures. The core molecular structure of steroids is a proven backbone in drug development. More than 100 different steroid molecules are approved by the U.S. Food and Drug Administration as therapeutics for a wide range of symptoms and diseases including inflammation and pain, cancer and bacterial infection. Steroidal therapeutics arguably make up the most successful class of medicine inspired by a natural product. All... Read More

Molecular Genetics of Chromosome 17 Tauopathies

Image The identification of mutations in the gene encoding the micro‐tubule associated protein tau in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP‐17) demonstrated that tau dysfunction can lead to neurodegeneration. At least 11 missense mutations and 1 deletion mutation (ΔK280) have been identified in exons 9–13 that encode the microtubule binding domains of tau. In addition, five mutations have been found close to the 5′ splice site of exon 10. The different FTDP‐17 mutations have multiple effects on the biology and function of tau. These varied pathogenic mechanisms likely explain the wide range of clinical and neuropathological... Read More

Assessment methods for solid waste management

Image Assessment methods are common tools to support decisions regarding waste management. The objective of this review article is to provide guidance for the selection of appropriate evaluation methods. For this purpose, frequently used assessment methods are reviewed, categorised, and summarised. In total, 151 studies have been considered in view of their goals, methodologies, systems investigated, and results regarding economic, environmental, and social issues. A goal shared by all studies is the support of stakeholders. Most studies are based on life cycle assessments, multi-criteria-decision-making, cost-benefit analysis, risk assessments, and benchmarking. Approximately 40% of the reviewed articles are life cycle... Read More

Invitation for Special Issue: Journal of Basic and Clinical Reproductive Sciences

Image Journal of Basic and Clinical Reproductive Sciences is an academic journal and aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc. in all areas of the field and making them freely available through online without any restrictions or any other subscriptions to researchers worldwide. The journal selects the articles to be published with a single bind, peer review system, following the practices of good scholarly journals. It supports the open access policy of making scientific research accessible to one... Read More

Types of Hemodialysis

Image Journal of Kidney Treatment and Diagnosis consists of the latest findings related to pathogenesis and treatment of kidney disease, hypertension, acid-base and electrolyte disorders, dialysis therapies, and kidney transplantation. In hemodialysis, the patient's blood is pumped through the blood compartment of a dialyzer, exposing it to a partially permeable membrane. The dialyzer is composed of thousands of tiny hollow synthetic fibers. The fiber wall acts as the semipermeable membrane. Blood flows through the fibers, dialysis solution flows around the outside of the fibers, and water and wastes move between these two solutions. The cleansed blood is then returned via the circuit... Read More

Child Psychology

Image Child Psychology Journal of Child Psychology aims to disseminate knowledge and promote discussion through the publication of peer-reviewed, high quality research papers on all topics related to like Child Psychology, Infant Behaviour, IQ, Cognitive Development, Speech & Language Development, Abnormal Development, Gender & Moral Developments, Social & Emotional Development, Physical Development, Memory Development, and Motor Development. Journal of Child psychology is devoted to publish original and unpublished manuscripts focusing on the issues and challenges related to Toddlerhood, Child-hood, Adolescence, Intellectual & Mental Development, Sexual Development, Thinking & Reasoning, Attention & Interest, and Parenting. Contributors are welcome to publish high quality clinical,... Read More

Diabetic Retinopathy

Image Diabetic Retinopathy Diabetic retinopathy is a diabetes complication that affects eyes. It's caused by damage to the blood vessels of the light-sensitive tissue at the back of the eye (retina). diabetic retinopathy symptoms may include: Spots or dark strings floating in your vision (floaters), Blurred vision, Fluctuating vision, Impaired color vision, Dark or empty areas in your vision, Vision loss. There are two types of diabetic retinopathy: Early diabetic retinopathy: This more common form of diabetic retinopathy called non proliferative diabetic retinopathy (NPDR) where new blood vessels aren't growing (proliferating). Advanced diabetic... Read More

Genome Sequencing Technique

Image Journal of Next Generation Sequencing & Applications is a peer reviewed medical journal that includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises peer review for the submitted manuscripts to ensure quality. Sequencing is the process of determining the precise order of nucleotides within the genome. It includes various methods or technologies that are used to determine the order of the four nucleotides in the DNA strand. The advent of rapid DNA sequencing methods has greatly accelerated biological and medical research... Read More

Robotic Approach Better Than Laparoscopic Approach

Image The treatment of rectal cancer is complex and responsible for sequelae due to the various therapeutic modalities, especially the surgical resection. The advent of minimally invasive surgery provided a faster postoperative recovery and a lower complication rate when compared to conventional surgery. The implementation of laparoscopic approach in rectal cancer was responsible for these better results, but the limitations of this method added to the development of robotics, raised the question of which minimally invasive method would be more advantageous in the approach of rectal cancer. Our paper published on Journal of Coloproctology this year (https://doi.org/10.1016/j.jcol.2019.05.003) addressed... Read More

Molecular Ecology

Image Ecology and Toxicology is a branch of science which deals with the relationships between organism and their natural environment and effects of harmful substances on organism at population community and ecosystem level. Journal of Ecology and Toxicology, a peer reviewed, Open Access Journal provides an open platform for eminent scientists around the globe to publish their scholarly work in field related to organism association with their ecological niche and effects incurred by various deleterious toxic substances to organism and their effects at each level of ecological hierarchy. Various regulatory approaches for toxic chemicals management are included in scope of Journal of Ecology and Toxicology. Ecological... Read More

Incineration Research

Image Advances in Recycling & Waste Management is a peer reviewed and open access journal publishes articles in the scientific society. The journal welcomes articles in the form of original articles, review articles, case reports, short communications etc. relevant fields. Researchers and Scientific experts of Advances in Recycling & Waste Management discipline are encouraged to publish innovative ideas in Open Peer-Review Journals. Advances in recycling Journals broadly covers Solid waste recycling, organic waste recycling, waste water recycling, agricultural waste recycling, sustainable production and consumption patterns, waste oil recycling, hazardous waste recycling, food waste recycling, nuclear waste recycling, industrial waste recycling, innovation... Read More

Molecular Biophysics

Image Journal of Molecular science is an official peer reviewed journal for the rapid publication of innovative research covering all aspects of molecular sciences and providing an advanced forum for molecular biology, molecular medicine and chemistry. Molecular Sciences is an integrative, complex, concerted and a multidisciplinary science dealing with the study of different type of molecules.It includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises a peer review process for the submitted manuscripts for the quality of publishing. Journal of Molecular Sciences... Read More

HIVES DISEASES

Image The Journal of Immune Disorder and Therapy  is a peer-reviewed, open access Journal aims to publish the latest developments in Autoimmune diseases, Rheumatology, Dermatology, Endocrinology, Molecular genetics, Cell biology etc. Immune system has long been recognized as the authoritative reference for the most current, clinically relevant and highest quality research in the field of immunology. Hives, is an outbreak of swollen, pale red bumps or plaques on the skin that appear suddenly either as a result of the body's reaction to certain allergens. Appear on the skin as red, very itchy,... Read More

VITILIGO DISORDER

Image The Journal of Immune Disorder and Therapy  is a peer-reviewed, open access Journal aims to publish the latest developments in Autoimmune diseases, Rheumatology, Dermatology, Endocrinology, Molecular genetics, Cell biology etc. Immune system has long been recognized as the authoritative reference for the most current, clinically relevant and highest quality research in the field of immunology.