Natural and artificial small RNAs
Journal of Molecular Cancer is an open access, peer reviewed, scholarly journal that aims to enhance our understanding on the genesis, diagnosis, consequences of cancer molecules by critiquing the literature on Molecular Cancer, Cell and Tumor Biology, Angiogenesis, Cancer Antigens, Cellular Signaling and Molecular Biology, Genetic And Molecular Profiling of Cancer, DNA Damage and Repair, Cell Cycle, Metastasis.
Since the failure of traditional therapy, gene therapy using functional DNA sequence and small RNA/DNA molecules(oligonucleotide) has become a promising avenue for cancer treatment. The discovery of RNA molecules has impelled researchersto investigate small regulatory RNA from various natural and artificial sources and determine a cogent target for controlling tumorprogression. Small regulatory RNAs are used for therapeutic silencing of oncogenes and aberrant DNA repair response genes.Despite their advantages, therapies based on small RNAs exhibit limitations in terms of stability of therapeutic drugs, precisionbaseddelivery in tissues, precision-based intercellular and intracellular targeting, and tumor heterogeneity-based responses. In thisstudy, we summarize the potential and drawbacks of small RNAs in nucleic acid therapeutics for cancer.
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Journal of Molecular Cancer
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